Updated
Reviewed
Management of Medication Toxicity or Intolerance
Rash and Hypersensitivity Reactions
Table 17k. Antiretroviral Therapy–Associated Adverse Effects and Management Recommendations—Rash and Hypersensitivity Reactions | |
---|---|
References
- Pelchen-Matthews A, Larsen JF, Shepherd L, et al. Hypersensitivity reactions, hepatotoxicity, and other discontinuations in persons receiving integrase strand transfer inhibitors: results from the EuroSIDA study. HIV Res Clin Pract. 2021;22(6):160-168. Available at: https://pubmed.ncbi.nlm.nih.gov/34779362.
- Yuan J, Guo S, Hall D, et al. Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent. AIDS. 2011;25(10):1271-1280. Available at: https://pubmed.ncbi.nlm.nih.gov/21505298.
- Vitezica ZG, Milpied B, Lonjou C, et al. HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz. AIDS. 2008;22(4):540-541. Available at: https://pubmed.ncbi.nlm.nih.gov/18301070.
- Tudor-Williams G, Cahn P, Chokephaibulkit K, et al. Etravirine in treatment-experienced, HIV-1-infected children and adolescents: 48-week safety, efficacy and resistance analysis of the Phase II PIANO study. HIV Med. 2014;15(9):513-524. Available at: https://pubmed.ncbi.nlm.nih.gov/24589294.
- Thomas SJ, Kilgore JT, Becken BA, Cunningham CK, Thompson AB. Raltegravir-associated drug-reaction with eosinophilia and systemic symptoms syndrome in a pediatric patient without characteristic human leukocyte antigen B*57:01 or B*53:01 alleles. J Pediatric Infect Dis Soc. 2021;10(3):363-366. Available at: https://pubmed.ncbi.nlm.nih.gov/32766769.
- Thomas M, Hopkins C, Duffy E, et al. Association of the HLA-B*53:01 allele with drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome during treatment of HIV infection with raltegravir. Clin Infect Dis. 2017;64(9):1198-1203. Available at: https://pubmed.ncbi.nlm.nih.gov/28369189.
- Shubber Z, Calmy A, Andrieux-Meyer I, et al. Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis. AIDS. 2013;27(9):1403-1412. Available at: https://pubmed.ncbi.nlm.nih.gov/23343913.
- Shah R, Nabiswa H, Okinda N, Revathi G, Hawken M, Nelson M. Prevalence of HLA-B*5701 in a Kenyan population with HIV infection. J Infect. 2018;76(2):212-214. Available at: https://pubmed.ncbi.nlm.nih.gov/28919349.
- Rutstein RM, Samson P, Fenton T, et al. Long-term safety and efficacy of atazanavir-based therapy in HIV-infected infants, children and adolescents: the Pediatric AIDS Clinical Trials Group protocol 1020A. Pediatr Infect Dis J. 2015;34(2):162-167. Available at: https://pubmed.ncbi.nlm.nih.gov/25232777.
- Ripamonti D, Benatti SV, Di Filippo E, Ravasio V, Rizzi M. Drug reaction with eosinophilia and systemic symptoms associated with raltegravir use: case report and review of the literature. AIDS. 2014;28(7):1077-1079. Available at: https://pubmed.ncbi.nlm.nih.gov/24685746.
- Puthanakit T, Bunupuradah T, Kosalaraksa P, et al. Prevalence of human leukocyte antigen-B*5701 among HIV-infected children in Thailand and Cambodia: implications for abacavir use. Pediatr Infect Dis J. 2013;32(3):252-253. Available at: https://pubmed.ncbi.nlm.nih.gov/22986704.
- Prasertvit P, Chareonyingwattana A, Wattanakrai P. Nevirapine patch testing in Thai human immunodeficiency virus infected patients with nevirapine drug hypersensitivity. Contact Dermatitis. 2017;77(6):379-384. Available at: https://pubmed.ncbi.nlm.nih.gov/28782122.
- Peter J, Choshi P, Lehloenya RJ. Drug hypersensitivity in HIV infection. Curr Opin Allergy Clin Immunol. 2019;19(4):272-282. Available at: https://pubmed.ncbi.nlm.nih.gov/31145192.
- Nishijima T, Gatanaga H, Teruya K, et al. Skin rash induced by ritonavir-boosted darunavir is common, but generally tolerable in an observational setting. J Infect Chemother. 2014;20(4):285-287. Available at: https://pubmed.ncbi.nlm.nih.gov/24507978.
- Nachman S, Alvero C, Teppler H, et al. Safety and efficacy at 240 weeks of different raltegravir formulations in children with HIV-1: a Phase 1/2 open label, non-randomised, multicentre trial. Lancet HIV. 2018;5(12):e715-e722. Available at: https://pubmed.ncbi.nlm.nih.gov/30527329.
- Martin C, Payen MC, De Wit S. Dolutegravir as a trigger for DRESS syndrome? Int J STD AIDS. 2018;29(10):1036-1038. Available at: https://pubmed.ncbi.nlm.nih.gov/29621952.
- Mallal S, Phillips E, Carosi G, et al. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008;358(6):568-579. Available at: https://pubmed.ncbi.nlm.nih.gov/18256392.
- Lefebvre M, Walencik A, Allavena C, et al. Rate of DRESS syndrome with raltegravir and role of the HLA-B*53: 01 allele. J Acquir Immune Defic Syndr. 2020;85(4):e77-e80. Available at: https://pubmed.ncbi.nlm.nih.gov/33136758.
- Kim GY, Anderson KR, Davis DMR, Hand JL, Tollefson MM. Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: a systematic review of the literature. J Am Acad Dermatol. 2020;83(5):1323-1330. Available at: https://pubmed.ncbi.nlm.nih.gov/32247873.
- Hayes E, Derrick C, Smalls D, Smith H, Kremer N, Weissman S. Short-term adverse events with BIC/FTC/TAF: postmarketing study. Open Forum Infect Dis. 2020;7(9):ofaa285. Available at: https://pubmed.ncbi.nlm.nih.gov/32908943.
- Hasan M, Yunihastuti E, Abdullah M. Incidence and predictors of nevirapine and efavirenz-associated rash among Indonesian HIV patients. Asian Pac J Allergy Immunol. 2020;12932/AP-080719-0596. Available at: https://pubmed.ncbi.nlm.nih.gov/32061245.
- Fillekes Q, Mulenga V, Kabamba D, et al. Is nevirapine dose escalation appropriate in young, African, HIV-infected children? AIDS. 2013;27(13):2111-2115. Available at: https://pubmed.ncbi.nlm.nih.gov/23595153.
- Dziuban EJ, Hughey AB, Stewart DA, et al. Stevens-Johnson syndrome and HIV in children in Swaziland. Pediatr Infect Dis J. 2013;32(12):1354-1358. Available at: https://pubmed.ncbi.nlm.nih.gov/23743542.
- du Toit JD, Kotze K, van der Westhuizen HM, Gaunt TL. Nevirapine-induced Stevens-Johnson syndrome in children living with HIV in South Africa. South Afr J HIV Med. 2021;22(1):1182. Available at: https://pubmed.ncbi.nlm.nih.gov/33824730.
- Borras-Blasco J, Navarro-Ruiz A, Borras C, Castera E. Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection. J Antimicrob Chemother. 2008;62(5):879-888. Available at: https://pubmed.ncbi.nlm.nih.gov/18653488.
- DiLorenzo MA, Medrano N, Chen JN, et al. Bictegravir-induced drug reaction with eosinophilia and systemic symptoms in a patient with acute human immunodeficiency virus. Open Forum Infect Dis. 2023;10(3):ofad066. Available at: https://pubmed.ncbi.nlm.nih.gov/36879628.
- Orkin C, Sadiq ST, Rice L, et al. Prospective epidemiological study of the prevalence of human leukocyte antigen (HLA)-B*5701 in HIV-1-infected UK subjects. HIV Med. 2010;11(3):187-192. Available at: https://pubmed.ncbi.nlm.nih.gov/19780860.
Management of Medication Toxicity or Intolerance
Rash and Hypersensitivity Reactions
Table 17k. Antiretroviral Therapy–Associated Adverse Effects and Management Recommendations—Rash and Hypersensitivity Reactions | |
---|---|
Download Guidelines
- Section Only PDF (123.84 KB)
- Full Guideline PDF (6.34 MB)
- Recommendations Only PDF (227.38 KB)
- Tables Only PDF (1.03 MB)
- Drug Tables Only PDF (2.38 MB)