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Clinical Guidelines

The federally approved clinical practice guidelines for HIV/AIDS are developed by panels of experts in HIV care. More information about the panels can be found in each set of guidelines.

The guidelines are available in multiple formats. The brief versions of the guidelines are compilations of the panels’ treatment recommendations and tables. The guidelines are being updated to comply with Executive Orders. Updated versions are being posted once available.

Search Guidelines

  • Perinatal HIV Clinical Guidelines (93)
  • HIV Clinical Guidelines: Pediatric ARV (86)
  • HIV Clinical Guidelines: Adult and Adolescent Opportunistic Infections (64)
  • HIV Clinical Guidelines: Adult and Adolescent ARV (62)
  • HIV Clinical Guidelines: Pediatric Opportunistic Infections (44)
  • Guidelines for Caring for People With HIV Displaced by Disasters (4)

Federally Approved Clinical Practice Guidelines for HIV/AIDS

HIV Clinical Guidelines: Adult and Adolescent ARV
Updated: September 12, 2024
HIV Clinical Guidelines: Adult and Adolescent Opportunistic Infections
Updated: April 23, 2025
HIV Clinical Guidelines: Pediatric ARV
Updated: December 19, 2024
HIV Clinical Guidelines: Pediatric Opportunistic Infections
Updated: June 05, 2025
Perinatal HIV Clinical Guidelines
Updated: June 12, 2025
Guidelines for Caring for People With HIV Displaced by Disasters
Updated: October 11, 2024
Archived Guidelines
Updated: December 31, 2024

Centers for Disease Control (CDC) Guideline Reports

Pre-exposure Prophylaxis (PrEP)

Pre-exposure Prophylaxis (PrEP)

Occupational Postexposure Prophylaxis (PEP)

Occupational Postexposure Prophylaxis (PEP)

Nonoccupational Postexposure Prophylaxis (nPEP)

Nonoccupational Postexposure Prophylaxis (nPEP)

Prevention with Persons with HIV

Prevention With Persons With HIV

Laboratory Testing

Laboratory Testing

Hormonal Contraception

Hormonal Contraception

HIV Counseling, Testing, and Referral

HIV Counseling, Testing, and Referral

Latest News

More News
Guideline
Update to the Perinatal HIV Clinical Guideline
June 12, 2025
Guideline
Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV
June 05, 2025
Guideline
Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV  
April 23, 2025

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