Updated
Reviewed
Apr. 07, 2021

Management of Medication Toxicity or Intolerance

Lactic Acidosis

Table 15g. Antiretroviral Therapy–Associated Adverse Effects and Management Recommendations—Lactic Acidosis
Table 15g. Antiretroviral Therapy–Associated Adverse Effects and Management Recommendations—Lactic Acidosis
   
   
   
   

 

References

General Reviews

  1. Fortuny C, Deya-Martinez A, Chiappini E, Galli L, de Martino M, Noguera-Julian A. Metabolic and renal adverse effects of antiretroviral therapy in HIV-infected children and adolescents. Pediatr Infect Dis J. 2015;34(5 Suppl 1):S36-43. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25629891.
  2. Margolis AM, Heverling H, Pham PA, Stolbach A. A review of the toxicity of HIV medications. J Med Toxicol. 2014;10(1):26-39. Available at: https://www.ncbi.nlm.nih.gov/pubmed/23963694.
  3. Tukei VJ, Asiimwe A, Maganda A, et al. Safety and tolerability of antiretroviral therapy among HIV-infected children and adolescents in Uganda. J Acquir Immune Defic Syndr. 2012;59(3):274-280. Available at: https://www.ncbi.nlm.nih.gov/pubmed/22126740.
  4. Bartlett AW, Mohamed TJ, Sudjaritruk T, et al. Disease- and treatment-related morbidity in adolescents with perinatal HIV infection in Asia. Pediatr Infect Dis J. 2019;38(3):287-292. Available at: https://www.ncbi.nlm.nih.gov/pubmed/30281549.
  5. Tshamala HK, Aketi L, Tshibassu PM, et al. The lipodystrophy syndrome in HIV-infected children under antiretroviral therapy: a first report from the Central Africa. Int J Pediatr. 2019;2019:7013758. Available at: https://www.ncbi.nlm.nih.gov/pubmed/30941184.
  6. Smith ZR, Horng M, Rech MA. Medication-induced hyperlactatemia and lactic acidosis: a systematic review of the literature. Pharmacotherapy. 2019;39(9):946-963. Available at: https://www.ncbi.nlm.nih.gov/pubmed/31361914.

Risk Factors

  1. Aperis G, Paliouras C, Zervos A, Arvanitis A, Alivanis P. Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. J Ren Care. 2011;37(1):25-29. Available at: https://www.ncbi.nlm.nih.gov/pubmed/21288314.
  2. Food and Drug Administration. Kaletra (lopinavir/ritonavir) [package insert]. 2020. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021251s055,021906s050lbl.pdf.
  3. Aboud M, Orkin C, Podzamczer D, et al. Efficacy and safety of dolutegravir-rilpivirine for maintenance of virological suppression in adults with HIV-1: 100-week data from the randomised, open-label, phase 3 SWORD-1 and SWORD-2 studies. Lancet HIV. 2019;6(9):e576-e587. Available at: https://www.ncbi.nlm.nih.gov/pubmed/31307948.
  4. Firnhaber C, Smeaton LM, Grinsztejn B, et al. Differences in antiretroviral safety and efficacy by sex in a multinational randomized clinical trial. HIV Clin Trials. 2015;16(3):89-99. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25979186.
  5. Fortuin-de Smidt M, de Waal R, Cohen K, et al. First-line antiretroviral drug discontinuations in children. PLoS One. 2017;12(2):e0169762. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28192529.
  6. Lim TY, Poole RL, Pageler NM. Propylene glycol toxicity in children. J Pediatr Pharmacol Ther. 2014;19(4):277-282. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25762872.
  7. Mamiafo CT, Moor VJ, Nansseu JR, Pieme CA, Tayou C, Yonkeu JN. Hyperlactatemia in a group of HIV patients living in Yaounde-Cameroon. AIDS Res Ther. 2014;11(1):2. Available at: https://www.ncbi.nlm.nih.gov/pubmed/24428886.
  8. Matthews LT, Giddy J, Ghebremichael M, et al. A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapy. PLoS One. 2011;6(4):e18736. Available at: https://www.ncbi.nlm.nih.gov/pubmed/21494566.
  9. Moren C, Noguera-Julian A, Garrabou G, et al. Mitochondrial evolution in HIV-infected children receiving first- or second-generation nucleoside analogues. J Acquir Immune Defic Syndr. 2012;60(2):111-116. Available at: https://www.ncbi.nlm.nih.gov/pubmed/22362155.
  10. Tetteh RA, Nartey ET, Lartey M, et al. Association between the occurrence of adverse drug events and modification of first-line highly active antiretroviral therapy in Ghanaian HIV patients. Drug Saf. 2016;39(11):1139-1149. Available at: https://www.ncbi.nlm.nih.gov/pubmed/27638659.
  11. Wester CW, Eden SK, Shepherd BE, et al. Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in Botswana: results from a clinical trial. AIDS Res Hum Retroviruses. 2012;28(8):759-765. Available at: https://www.ncbi.nlm.nih.gov/pubmed/22540188.

Monitoring and Management

  1. Barlow-Mosha L, Eckard AR, McComsey GA, Musoke PM. Metabolic complications and treatment of perinatally HIV-infected children and adolescents. J Int AIDS Soc. 2013;16(1):18600. Available at: https://www.ncbi.nlm.nih.gov/pubmed/23782481.
  2. Claessens YE, Cariou A, Monchi M, et al. Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine. Crit Care Med. 2003;31(4):1042-1047. Available at: https://www.ncbi.nlm.nih.gov/pubmed/12682470.
  3. Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014;371(24):2309-2319. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25494270.
  4. Marfo K, Garala M, Kvetan V, Gasperino J. Use of Tris-hydroxymethyl aminomethane in severe lactic acidosis due to highly active antiretroviral therapy: a case report. J Clin Pharm Ther. 2009;34(1):119-123. Available at: https://www.ncbi.nlm.nih.gov/pubmed/19125910.
  5. Jung B, Martinez M, Claessens YE, et al. Diagnosis and management of metabolic acidosis: guidelines from a French expert panel. Ann Intensive Care. 2019;9(1):92. Available at: https://www.ncbi.nlm.nih.gov/pubmed/31418093.

 

Management of Medication Toxicity or Intolerance

Lactic Acidosis

Table 15g. Antiretroviral Therapy–Associated Adverse Effects and Management Recommendations—Lactic Acidosis
Table 15g. Antiretroviral Therapy–Associated Adverse Effects and Management Recommendations—Lactic Acidosis
   
   
   
   

 

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