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What's New in the Guidelines
… reverse transcriptase inhibitors, (i.e., tenofovir disoproxil fumarate or tenofovir alafenamide [TAF] with 3TC or FTC; ABC and 3TC). …
Candida Infections
… but itraconazole may increase exposures and AEs from tenofovir disoproxil fumarate and tenofovir alafenamide. Most integrase strand transferase …
Preventing HIV Transmission During Infant Feeding
… infant. 92 NRTIs show more variability than PIs and NNRTIs. Tenofovir concentrations from tenofovir disoproxil fumarate (TDF) are very low in breast … Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk …
COVID-19
… of HIV (e.g., lopinavir/‌ritonavir, boosted darunavir, or tenofovir disoproxil fumarate/emtricitabine) have efficacy …
Clinical and Laboratory Monitoring of Pediatric HIV Infection
… HgbA1C = glycosylated hemoglobin; RPV = rilpivirine; TAF = tenofovir alafenamide; TB = tuberculosis; TDF = tenofovir disoproxil fumarate Table 7. Primary U.S. Food and …
What to Start: Antiretroviral Treatment Regimens Recommended for Initial Therapy in Infants and Children With HIV
… fixed-dose combination (FDC) tablet BIC/emtricitabine (FTC)/tenofovir alafenamide (TAF). INSTI-based regimens have … that include TAF have varying weight and age requirements. Tenofovir disoproxil fumarate (TDF) plus 3TC or FTC for … (DRV/r), or lopinavir/ritonavir (LPV/r) increases plasma tenofovir (TFV) concentrations and the risk of …
Special Considerations for Antiretroviral Therapy Use in Adolescents With HIV
… Many ARV drugs (e.g., abacavir, emtricitabine, lamivudine, tenofovir disoproxil fumarate [TDF], some protease …
Hepatitis B Virus Infection
… HBV is recommended; the preferred regimen should include tenofovir (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) and either lamivudine (3TC) or …
Hepatitis C Virus Infection
… the following: Velpatasvir can increase concentrations of tenofovir disoproxil fumarate and lead to tenofovir-related renal toxicity. It is unclear at this time whether this is also the case with tenofovir alafenamide. Nevertheless, care should be taken in …
Herpes Simplex Virus
… . Abdool Karim SS, Abdool Karim Q, Kharsany AB, et al. Tenofovir gel for the prevention of herpes simplex virus …
Overview
… caused by atazanavir, renal tubulopathy caused by tenofovir disoproxil fumarate) usually can be managed by … . Hill A, Hughes SL, Gotham D, Pozniak AL. Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in …
Central Nervous System Toxicity
… al. Fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide in adolescents and children with HIV: … tolerability of bictegravir combined with emtricitabine/tenofovir alafenamide in clinical practice. Antivir Ther . … co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir DF versus continuation of non-nucleoside reverse …
Dyslipidemia
… in people receiving integrase strand-transfer inhibitors, tenofovir alafenamide, or both compared with other … N, Margusino-Framinan L, et al. Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV-infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with …
Lactic Acidosis
… acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. J Ren Care . … M, Matsumoto M, Sawamura M. Severe lactic acidosis during tenofovir disoproxil fumarate and cobicistat combination for … Whitsett M, Papadopoulos Z, et al. Successful treatment of tenofovir alafenamide-induced lactic acidosis: a case …
Lipodystrophies and Weight Gain
… Infections Cohort Collaboration Study G. Weight gain on tenofovir alafenamide fumarate-based therapy compared to tenofovir disoproxil fumarate- and abacavir-based therapy in … Townsend CL, Milanzi E, et al. Effectiveness and safety of tenofovir alafenamide in children and adolescents living …
Nephrotoxic Effects
… . Campbell L, Barbini B, Cromarty B, et al. Safety of tenofovir alafenamide in people with HIV who experienced proximal renal tubulopathy on tenofovir. AIDS. 2024;38(9):1442-1445. Available at: … . Gupta SK, Post FA, Arribas JR, et al. Renal safety of tenofovir alafenamide vs. tenofovir disoproxil fumarate: a …
Osteopenia and Osteoporosis
… S, et al. Efficacy, safety and pharmacokinetics of tenofovir disoproxil fumarate in virologic-suppressed … B, Wang S, Cheung AM, Mishra S, Tan DH. The effect of tenofovir disoproxil fumarate on bone mineral density: a … X, et al. Vitamin D and calcium supplementation reverses tenofovir-caused bone mineral density loss in people taking …
Modifying Antiretroviral Regimens in Children With Sustained Virologic Suppression on Antiretroviral Therapy
… include coformulated bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) (Biktarvy) or FTC/TAF … weighing ≥45 kg showed that switching to the FDC DOR/3TC/tenofovir disoproxil (TDF) resulted in maintained … no known mutations associated with resistance to DRV or tenofovir. Must be taken with food. Aged ≥12 years Weighing …
Recognizing and Managing Antiretroviral Treatment Failure
… nucleos(t)ide reverse transcriptase inhibitors, (i.e., tenofovir disoproxil fumarate or tenofovir alafenamide with lamivudine (3TC) or … therapies included abacavir (ABC) and lamivudine (3TC), tenofovir disoproxil fumarate (TDF) and 3TC or TDF and …
Overview
… Inhibitors (NRTIs) Abacavir Emtricitabine Lamivudine Tenofovir alafenamide Tenofovir disoproxil fumarate Zidovudine Non-Nucleoside …