What are the most important things to know about zidovudine?
Zidovudine can cause serious, life-threatening side effects. These includeContact your health care provider right away if you have any of the following symptoms that could be signs of a hypersensitivity reaction: reaction or rash, a buildup of in the blood ( ), problems, muscle weakness ( ), and blood disorders, such as extremely reduced numbers of red blood cells (severe ) or reduced numbers of white blood cells ( ).
- Blistering or peeling of the skin
- Difficulty breathing or swallowing
- Swelling of the eyes, face, tongue, lips, or throat
- Nausea or vomiting
- Pain in the upper right part of your stomach
- Loss of appetite
- Extreme tiredness
- Dizziness or lightheadedness
- Fast or irregular heartbeat
- Trouble breathing
- Dark-colored urine
- Light-colored bowel movements
- Yellowing of your skin or the whites of your eyes ( )
- Feeling cold, especially in your arms or legs
- Unusual muscle pain
- Muscle pain
- Unusual bleeding or bruising
- Fever, chills, or other symptoms of
- Unusual tiredness or weakness
- Pale skin
Worsening of liver disease (sometimes resulting in death) has occurred in people with both HIV and ribavirin. If you are taking zidovudine as well as interferon with or without ribavirin and you experience side effects, tell your health care provider.(HCV) who were taking HIV medicines and also being treated for HCV infection with with or without
While taking zidovudine, it is important to keep all of your appointments with your health care provider.
What is zidovudine?
Zidovudine is a prescription medicine approved by the U.S.
- To treat HIV infection in adults and children 4 weeks of age and older. When zidovudine is used to treat HIV infection, the medicine is always used in combination with other HIV medicines.
- To prevent mother-to-child ( ) of HIV. When used to prevent mother-to-child transmission, zidovudine is given to women with HIV during pregnancy and childbirth and to their infants for 6 weeks after birth.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, don't cut down on, skip, or stop taking them unless your health care provider tells you to.
Zidovudine may also be used off-label to treat some conditions associated with human herpesvirus-8 (HHV-8) infection in people with HIV. For information on the off-label, HIV-related uses of zidovudine, please refer to the HHV-8 section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV.
What should I tell my health care provider before taking zidovudine?
Before taking zidovudine, tell your health care provider:
- If you are allergic to zidovudine, latex, or any other medicines.
- If you have or have ever had liver or kidney disease.
- If you have or have ever had bleeding problems, too few red blood cells (anemia), or other blood problems.
- If you have problems.
- If you have any muscle diseases or swelling of the muscles.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking zidovudine during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking zidovudine.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Zidovudine may affect the way other medicines or products work, and other medicines or products may affect how zidovudine works. Taking zidovudine together with certain medicines or products may cause serious, life-threatening side effects.
How should I take zidovudine?
Zidovudine (brand name: Retrovir) comes in the following forms and strengths:
- 300-mg tablets
- 100-mg capsules
- 10-mg/mL syrup
- 20-mL/200-mg single-use vials for (IV) injection
Take zidovudine according to your health care provider’s instructions.
Take zidovudine with or without food.
Vials of zidovudine for IV injection contain 200 mg of zidovudine in a 20 mL solution. Before use, the appropriateof zidovudine is drawn from the vial and diluted with a dextrose (sugar)/water solution. The diluted medicine is injected slowly (infused) over a specified period of time through a needle or catheter into a vein.
If you take too much zidovudine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take zidovudine, see the FDA drug labels for zidovudine tablets and zidovudine capsules, syrup, and solution for IV injection. For more information on how to take zidovudine for IV injection, see the drug summary from .
What should I do if I forget a dose?
If you miss a dose of zidovudine, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can zidovudine cause?
Zidovudine may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the ClinicalInfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of zidovudine can be serious. Serious side effects of zidovudine include lactic acidosis, liver problems, myopathy, and blood disorders such as severe anemia or neutropenia. (See section above: What are the most important things to know about zidovudine?)Other possible side effects of zidovudine include:
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Loss of body fat ( ).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of zidovudine. To learn more about possible side effects of zidovudine, read the drug label oror talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should zidovudine be stored?
- Store zidovudine tablets at room temperature, 68°F to 77°F (20°C to 25°C).
- Store zidovudine capsules and syrup between 59°F and 77°F (15°C to 25°C). Protect zidovudine capsules from moisture.
- Store vials of zidovudine for IV injection between 59°F and 77°F (15°C to 25°C) and protect them from light. Once zidovudine for IV injection is diluted, use the solution within 8 hours if stored at 59°F to 77°F (15°C to 25°C) or within 24 hours if refrigerated at 36°F to 46°F (2°C to 8°C).
- Keep zidovudine in the container that it came in and keep the container tightly closed.
- Do not use zidovudine if the original seal over the container opening is broken or missing.
- Throw away zidovudine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep zidovudine and all medicines out of reach of children.
Where can I find more information about zidovudine?
More information about zidovudine is available:
- The FDA drug labels for zidovudine tablets and zidovudine capsules, syrup, and solution for IV injection. The Patient Counseling Information section of the labels includes information for people taking zidovudine.
- The zidovudine drug summary from MedlinePlus includes information for people taking zidovudine for IV injection.
- Recommendations on the off-label HIV-related use of zidovudine from the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, prepared by the , the , and the HIV Medicine Association of the Diseases Society of America.
- Zidovudine-related research studies, from the ClinicalInfo database of study summaries.
- A list of FDA-approved HIV medicines, from ClinicalInfo.
Main number: 877-844-8872
Patient assistance (ViiV Connect): 844-588-3288
Last Reviewed: January 20, 2020