What is Jynneos?
Jynneos is aapproved in September 2019 by the U.S. (FDA) to prevent smallpox and monkeypox in adults who are at high risk for smallpox or monkeypox infection. (Smallpox and monkeypox are related viral that can cause similar symptoms, but monkeypox symptoms are generally milder than smallpox symptoms and monkeypox is usually not fatal.)
In the context of the current monkeypox public health emergency in the United States, FDA issued an Emergency Use Authorization (EUA) for the Jynneos vaccine on August 9, 2022. (An EUA allows FDA to expedite the availability and use of medical products during a public health emergency.) The EUA for the Jynneos vaccine increases the number of vaccine available by allowing an alternative dosing regimen and also allows for the use of the vaccine in people younger than 18 years of age who are at high risk of monkeypox infection.
Some reports suggest that monkeypox could be an What is an Opportunistic Infection? fact sheet.(OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened —such as people with HIV—than in people with healthy immune systems. Current data does not indicate that people with HIV have a higher likelihood of getting monkeypox than people without HIV. People with advanced HIV or who do not have on ART can be at higher risk of severe monkeypox disease. To learn more about OIs, read the HIVinfo
The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents provides additional information on monkeypox and references the Centers For Disease Control and Prevention (CDC) webpage Clinical Considerations for Treatment and Prophylaxis of Monkeypox Virus Infection in People with HIV. The CDC webpage has information on the management of monkeypox in people with HIV, including recommendations on the use of Jynneos to prevent monkeypox infection in people with HIV who meet the for .
To learn more about vaccines to prevent monkeypox infection, including current recommendations on who should get vaccinated, visit the CDC webpages Monkeypox: Vaccination Strategies and Monkeypox: Vaccines. For more information about monkeypox, visit the CDC webpage Monkeypox.
What should I tell my health care provider before receiving Jynneos?
Before receiving Jynneos, tell your health care provider:
- If you are allergic to any ingredients in Jynneos or any medicines. Tell your health care provider if you have ever had any reactions to a previous of Jynneos or to any other vaccines, including a smallpox vaccine.
- About any medical conditions you have or have had, including severe or life-threatening allergies or a weakened
- About any health conditions that may prevent you from receiving medicine by injection.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of receiving Jynneos during pregnancy.
- If you are breast/chestfeeding or plan to breast/chestfeed. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Jynneos may affect the way other medicines or products work, and other medicines or products may affect how Jynneos works. Ask your health care provider if there are interactions between Jynneos and the medicines you take.
Ask your health care provider about possible side effects from getting a Jynneos vaccine. Your health care provider will tell you what to do if you have side effects.
How is Jynneos given?
A health care provider gives the Jynneos vaccine. Vaccination with Jynneos is usually given as a series of two injections, with a 4-week interval between each. Read any printed information that your health care provider gives you about the Jynneos vaccine.
Where can I find more information about Jynneos vaccine?
- Recommendations on the HIV-related use of Jynneos, from the CDC webpage Clinical Considerations for Treatment and Prophylaxis of Monkeypox Virus Infection in People with HIV.
- This Patient Version drug summary is based on the following FDA label(s): Injection (suspension). The Patient Counseling Information section of the label includes information for people receiving Jynneos.
- Smallpox/Monkeypox (Jynneos) Vaccine Information Statement (VIS) available from the CDC.
- Monkeypox Fast Facts: Jynneos available from FDA.
- The American Hospital Formulary Service (AHFS) Patient Medication Information for smallpox/monkeypox vaccine available from MedlinePlus.
- Jynneos-related research studies, from ClinicalTrials.gov. (The ClinicalTrials.gov search can be modified so that you can get results that better match your interests. To learn more about the ClinicalTrials.gov search features, please see How to Search.)