What are the most important things to know about etravirine?
Etravirine can cause serious, life-threatening side effects. These include severe skin rash and allergic reactions.Contact your health care provider or get medical help right away if you have a rash along with any of the following symptoms:
- Blisters or sores in your mouth
- Blistering or peeling skin, including the area around your mouth or eyes
- Trouble breathing
- Swelling of your mouth, lips, or face
- Yellowing of your skin or the whites of your eyes ( )
- Redness or swelling of your eyes
- Generally not feeling well
- Extreme tiredness
- Aching muscles or joints
- Loss of appetite
- Dark-colored urine
- Light-colored bowel movements
- Pain, aching, or tenderness on the right side of your stomach area
While taking etravirine, it is important to keep all of your appointments with your health care provider.
What is etravirine?
Etravirine is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children 2 years of age and older who have taken HIV medicines in the past. Etravirine is always used in combination with other HIV medicines.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking etravirine?
Before taking etravirine, tell your health care provider:
- If you are allergic to etravirine or any other medicines.
- If you have problems, including (HBV) or (HCV).
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking etravirine during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking etravirine.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products, including St. John's wort, you are taking or plan to take. Etravirine may affect the way other medicines or products work, and other medicines or products may affect how etravirine works. Taking etravirine together with certain medicines or products may cause serious side effects.
How should I take etravirine?
Etravirine (brand name: Intelence) comes in tablet form in three different strengths:
- 25-mg tablets
- 100-mg tablets
- 200-mg tablets
Take etravirine according to your health care provider’s instructions.
Always take etravirine after a meal. Do not take etravirine on an empty stomach. Swallow the tablets whole with a glass of water. Do not chew the tablets.
If you are unable to swallow the etravirine tablets whole, place the tablets in a glass containing a teaspoon of water. (If needed, add more water to cover the tablets.) Do not put the tablets in other liquids. Stir well until the water looks milky. At this step, you may add a small amount of water, orange juice, or milk to make the mixture easier to drink. Then drink the mixture right away. Rinse the glass with water, orange juice, or milk several times, and completely swallow the rinse each time to make sure you take the entireof etravirine. Avoid using warm (more than 104°F/40°C) or carbonated beverages when taking etravirine tablets.
Always take etravirine in combination with other HIV medicines.
If you take too much etravirine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take etravirine, see the FDA drug label.
What should I do if I forget a dose?
If you miss a dose of etravirine within 6 hours of the time you usually take it, take your dose after a meal as soon as possible. Then take your next dose at the regularly scheduled time. If you miss a dose by more than 6 hours of the time you usually take it, wait and then take the next dose at the regularly scheduled time. Do not take more than your prescribed dose to make up for a missed dose.
What side effects can etravirine cause?
Etravirine may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the ClinicalInfofact sheet on HIV Medicines and Side Effects for more information.
Some side effects of etravirine can be serious. Serious side effects of etravirine include severe skin rash and allergic reactions. (See section above: What are the most important things to know about etravirine?)
Other possible side effects of etravirine include:
- Changes in body fat ( ).
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Tingling, numbness, or pain in your hands or feet ( ) (in adults).
- Diarrhea (in children).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of etravirine. To learn more about possible side effects of etravirine, read the drug label oror talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should etravirine be stored?
- Store etravirine at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep etravirine in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture. Do not eat the desiccant packets.
- Do not use etravirine if the original seal over the container opening is broken or missing.
- Throw away etravirine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep etravirine and all medicines out of reach of children.
Where can I find more information about etravirine?
More information about etravirine is available:
Main number: 800-526-7736
Patient assistance: 800-652-6227
Janssen CarePath: 866-836-0114
The above Patient Version drug summary is based on the following FDA label(s): Tablet.
Last Reviewed: October 10, 2019