Drug information

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Pronounce:
Brand Name:
Reyataz
Other Names:
ATV, atazanavir sulfate
Drug Class:
Protease Inhibitors (PIs)
Drug Image(s): (Click to enlarge)
 
What are the most important things to know about atazanavir? What are the most important things to know about atazanavir?

What are the most important things to know about atazanavir?

 

Atazanavir can cause serious, life-threatening side effects. These include changes in heart rhythm, severe skin rash and allergic reactions, liver problems, and drug interactions.

Contact your health care provider right away if you have any of the following symptoms that could be signs of a change in your heart rhythm:

  • Dizziness
  • Lightheadedness

Contact your health care provider right away if you develop a rash while taking atazanavir. Stop taking atazanavir and get medical help right away if you develop a rash with any of the following symptoms:

  • General ill feeling
  • Extreme tiredness
  • Muscle or joint aches
  • Fever
  • Blistering or peeling skin
  • Blisters or sores in your mouth
  • Redness or swelling of the eyes (conjunctivitis)
  • Swelling of your face, lips, mouth, tongue, or throat
  • Trouble breathing or swallowing

Some people taking atazanavir may develop liver problems. People with a history of hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV) or who have elevated results on liver function tests may have an increased risk of developing worsening liver problems while taking atazanavir. Liver function tests may be done before and during treatment with atazanavir.

Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:

  • Yellowing of your skin or the whites of your eyes (jaundice)
  • Dark-colored urine
  • Light-colored bowel movements
  • Loss of appetite for several days or longer
  • Nausea or vomiting
  • Pain, aching, or tenderness on the right side of your stomach/abdominal area
  • Itching

Taking atazanavir with certain medicines may result in serious, life-threatening side effects. Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

While taking atazanavir, it is important to keep all of your appointments with your health care provider.

What is atazanavir?What is atazanavir?

What is atazanavir?

 

Atazanavir (brand name: Reyataz) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 months of age and older who weigh at least 11 lb (5 kg). Atazanavir is always used in combination with other HIV medicines.

For more information on the use of atazanavir in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.

HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.

What should I tell my health care provider before taking atazanavir?What should I tell my health care provider before taking atazanavir?

What should I tell my health care provider before taking atazanavir?

 

Before taking atazanavir, tell your health care provider:

  • If you are allergic to atazanavir or any other medicines.
  • If you have heart problems.
  • If you have liver problems, including hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV).
  • If you have phenylketonuria (PKU). The artificial sweetener (aspartame) in atazanavir oral powder contains phenylalanine. Phenylalanine may be harmful to people with PKU.
  • If you have kidney problems.
  • If you are receiving kidney dialysis treatment.
  • If you have diabetes.
  • If you have hemophilia.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking atazanavir during pregnancy. Atazanavir must be taken with ritonavir during pregnancy. If you take atazanavir during your pregnancy, after your baby is born, tell your health care provider if your baby’s skin or the white part of their eyes turns yellow. For more information on the use of atazanavir during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States.
  • If you are breastfeeding or plan to breastfeed. For women with HIV in the United States, the Guideline does not recommend breastfeeding. Before your baby is born, or if you are already breastfeeding, talk to your health care provider to discuss alternative options for feeding your baby.
  • If you are using hormone-based birth control (such as injections, vaginal rings, implants, a contraceptive patch, or birth control pills). Atazanavir may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking atazanavir. For more information about using birth control and HIV medicines at the same time, view the HIVinfo HIV and Birth Control infographic.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. Johns’ wort) you are taking or plan to take. Atazanavir may affect the way other medicines or products work, and other medicines and products may affect how atazanavir works. Taking atazanavir together with certain medicines or products may cause serious, life-threatening side effects.
How should I take atazanavir?How should I take atazanavir?

How should I take atazanavir?

 

Atazanavir comes in the following forms and strengths:

  • 150-mg, 200-mg, and 300-mg capsules
  • Oral powder (50 mg of atazanavir per packet)

Atazanavir capsules are for use in adults and in children 6 years of age and older who weigh at least 33 pounds (15 kg). Atazanavir oral powder must be taken with ritonavir and is for use in children 3 months of age and older who weigh at least 11 pounds (5 kg).

Take atazanavir according to your health care provider’s instructions.

Take atazanavir with food. Swallow the capsules whole. Do not open the capsules.

Atazanavir oral powder must be mixed with food or liquid. If atazanavir oral powder is mixed with water, your child must eat food right after taking the oral powder and water mixture. Give ritonavir right away after your child has taken atazanavir oral powder mixed with food or liquid. For information about the correct way to mix and give a dose of atazanavir oral powder to your child, see the “Instructions for Use” that comes with the medicine.

Always take atazanavir in combination with other HIV medicines.

If you have taken too much atazanavir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take atazanavir, see the FDA drug label.

What should I do if I forget a dose?What should I do if I forget a dose?

What should I do if I forget a dose?

 

If you miss a dose of atazanavir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can atazanavir cause?What side effects can atazanavir cause?

What side effects can atazanavir cause?

 

Atazanavir may cause side effects. Some side effects of atazanavir can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of atazanavir include:

  • Mild rash.
  • Chronic kidney disease.
  • Kidney stones. Contact your health care provider if you have pain in your lower back or lower stomach/abdominal area, blood in your urine, or pain when urinating.
  • Gallbladder stones. Contact your health care provider right away if you develop symptoms of gallbladder problems (pain in your right or middle upper stomach area, fever, nausea and vomiting, or jaundice).
  • New or worsening diabetes and high blood sugar (hyperglycemia).
  • Changes in your immune system (called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
  • Changes in body fat (lipodystrophy syndrome).
  • Increased bleeding problems in people with hemophilia.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of atazanavir. To learn more about possible side effects of atazanavir, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should atazanavir be stored?How should atazanavir be stored?

How should atazanavir be stored?

 

  • Store atazanavir capsules at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep atazanavir capsules in the container that they came in and keep the container tightly closed.
  • Store atazanavir oral powder at a temperature of 68°F to 86°F (20°C to 30°C).
  • Keep atazanavir oral powder in the original packet. Do not open until ready to use.
  • After atazanavir oral powder is mixed with food or liquid, it may be kept at a temperature of 68°F to 86°F (20°C to 30°C) for up to 1 hour. Use atazanavir oral powder within 1 hour after mixing with food or liquid.
  • Do not use atazanavir if the original seal over the container opening is broken or missing.
  • Throw away atazanavir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep atazanavir and all medicines out of reach of children.
Where can I find more information about atazanavir?Where can I find more information about atazanavir?

Where can I find more information about atazanavir?

 

Manufacturer Information

Bristol-Myers Squibb
Main number: 800-332-2056
Patient assistance: 800-721-8909

 

Last Reviewed: May 14, 2021