What are the most important things to know about atazanavir?
Atazanavir can cause serious, life-threatening side effects. These include changes in heart rhythm, severe rash,problems, and life-threatening drug interactions.
Contact your health care provider right away if you have any of the following symptoms that could be signs of a change in your heart rhythm:
Stop taking atazanavir and contact your health care provider right away if you have a severe rash or a rash with any of the following symptoms:
- General ill feeling or flu-like symptoms
- Muscle or joint aches
- Redness or swelling of the eyes ( )
- Mouth sores
- Swelling of your face
- A painful, warm, or red lump under your skin
Atazanavir can cause existing liver problems, including(HBV) or (HCV), to get worse. Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Pain in the stomach area (abdominal pain)
While taking atazanavir, it is important to keep all of your appointments with your health care provider.
What is atazanavir?
Atazanavir is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children 3 months of age and older who weigh at least 11 lb (5 kg). Atazanavir is always used in combination with other HIV medicines.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking atazanavir?
Before taking atazanavir, tell your health care provider:
- If you are allergic to atazanavir or any other medicines.
- If you have heart problems.
- If you have liver problems, including B infection (HBV) or hepatitis C virus infection (HCV).
- If you have phenylketonuria (PKU). The artificial sweetener in atazanavir oral powder (aspartame) contains phenylalanine. Phenylalanine may be harmful to people with PKU.
- If you are receiving kidney dialysis treatment.
- If you have .
- If you have .
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking atazanavir during pregnancy. If you take atazanavir during your pregnancy, after your baby is born, tell your health care provider if your baby’s skin or the white part of their eyes turns yellow.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking atazanavir.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Atazanavir may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking atazanavir. For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. Johns’ wort) you are taking or plan to take. Atazanavir may affect the way other medicines or products work, and other medicines and products may affect how atazanavir works. Taking atazanavir together with certain medicines or products may cause serious, life-threatening side effects.
How should I take atazanavir?
Atazanavir (brand name: Reyataz) comes in the following forms and strengths:
- 150-mg, 200-mg, and 300-mg capsules
- Oral powder (50 mg of atazanavir per packet)
Atazanavir capsules are for use in adults and in children 6 years of age and older. Atazanavir oral powder must be taken with ritonavir and is for use in children 3 months of age and older who weigh at least 11 pounds (5 kg).
Take atazanavir according to your health care provider’s instructions.
Take atazanavir with food. Swallow the capsules whole. Do not open the capsules.
Atazanavir oral powder must be mixed with food or liquid. If atazanavir oral powder is mixed with water, your child must eat food right after taking the oral powder and water mixture. Give ritonavir right away after your child has taken atazanavir oral powder mixed with food or liquid. For complete instructions on using atazanavir oral powder, see the Patient Information leaflet that comes with the medicine.
Always take atazanavir in combination with other HIV medicines.
If you take too much atazanavir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take atazanavir, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof atazanavir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can atazanavir cause?
Atazanavir may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the ClinicalInfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of atazanavir can be serious. Serious side effects of atazanavir include changes in heart rhythm, severe rash, liver problems, and life-threatening drug interactions. (See section above: What are the most important things to know about atazanavir?)
Other possible side effects of atazanavir include:
- Mild rash.
- Chronic kidney disease.
- Kidney stones. Contact your health care provider if you have pain in your lower back or lower stomach area, blood in your urine, or pain when urinating.
- Gallbladder problems. Contact your health care provider right away if you develop symptoms of gallbladder problems (pain in your right or middle upper stomach area, fever, nausea and vomiting, or jaundice).
- Diabetes and high blood sugar ( ).
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Changes in body fat ( ).
- Increased bleeding problems in people with hemophilia.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of atazanavir. To learn more about possible side effects of atazanavir, read the drug label oror talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should atazanavir be stored?
- Store atazanavir capsules at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep atazanavir capsules in the container that they came in and keep the container tightly closed.
- Store atazanavir oral powder below 86°F (30°C).
- Keep atazanavir oral powder in the original packet. Do not open until ready to use.
- After atazanavir oral powder is mixed with food or liquid, it may be kept at room temperature, 68°F to 86°F (20°C to 30°C), for up to 1 hour. Use atazanavir oral powder within 1 hour after mixing with food or liquid.
- Do not use atazanavir if the original seal over the container opening is broken or missing.
- Throw away atazanavir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep atazanavir and all medicines out of reach of children.
Where can I find more information about atazanavir?
More information about atazanavir is available:
Main number: 800-332-2056
Patient assistance: 888-281-8981
The above Patient Version drug summary is based on the following FDA label(s): Capsule (gelatin coated), oral powder.
Last Reviewed: May 21, 2020