What is amphotericin B?
Amphotericin B is anprescription medicine approved by the U.S. (FDA) for the treatment of several types of fungal infections, such as and . Amphotericin B is also FDA-approved for the treatment of two forms of , which is a parasitic . The FDA-approved uses for amphotericin B vary depending on the of the drug.
Many of the infections for which amphotericin B treatment is FDA-approved are opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the What is an Opportunistic Infection? fact sheet.
How is amphotericin B used in people with HIV?
The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV include recommendations on the uses of amphotericin B to:
- Treat histoplasmosis, cryptococcosis, , esophageal , leishmaniasis infections (including visceral leishmaniasis and leishmaniasis) and talaromycosis (also known as ) in people with HIV
- Prevent visceral leishmaniasis from recurring (called ) in people with HIV
The recommended uses may not always be consistent with FDA-approved uses of amphotericin B. See the guidelines for complete information on recommended uses of amphotericin B in adults and adolescents with HIV. Some recommended uses, such as uses in certain rare circumstances, may have been omitted above.
What should I tell my health care provider before taking amphotericin B?
Before taking amphotericin B, tell your health care provider:
- If you are allergic to amphotericin B or any other medicines.
- About any medical conditions you have or have had.
- About any health conditions that may prevent you from receiving medicine by .
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking amphotericin B during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Amphotericin B may affect the way other medicines or products work, and other medicines or products may affect how amphotericin B works. Ask your health care provider if there are interactions between amphotericin B and the other medicines you take.
Ask your health care provider about possible side effects from amphotericin B. Your health care provider will tell you what to do if you have side effects.
How should I take amphotericin B?
Take amphotericin B according to your health care provider’s instructions. Your health care provider will tell you how much amphotericin B to take and when to take it. Before you start amphotericin B and each time you get a refill, read any printed information that comes with your medicine.
How should amphotericin B be stored?
- Amphotericin B comes in different formulations. Each formulation has its own FDA label. Please see the FDA labels for specific instructions on how to store the different formulations.
- Do not use amphotericin B if the original seal on the carton is broken or missing.
- Throw away amphotericin B that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep amphotericin B and all medicines out of reach of children.
Where can I find more information about amphotericin B?
More information about amphotericin B is available:
- Recommendations on the HIV-related uses of amphotericin B, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, prepared by the , the , and the HIV Medicine Association of the Diseases Society of America
- Amphotericin B-related research studies, from the Clinical Info database of study summaries
The above Patient Version drug summary is based on the following FDA label(s): Injection (amphotericin B lipid complex); Injection (powder, lyophilized, for solution; amphotericin B deoxycholate); Injection (powder, lyophilized, for solution; amphotericin B liposome).
Last Reviewed: October 3, 2019