Drug Database: Lamivudine / Tenofovir Disoproxil Fumarate

What is Cimduo?What is Cimduo?

What is Cimduo?

Cimduo is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children weighing at least 77 lb (35 kg). Cimduo is always used in combination with other HIV medicines.

Cimduo contains two different medicines: lamivudine and tenofovir disoproxil fumarate.

For more information on the use of Cimduo in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.

HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.

Because lamivudine and tenofovir disoproxil fumarate are also effective against HBV infection, Cimduo may be included as part of an antiretroviral therapy (ART) regimen to treat both HIV and HBV infection in people with HIV/HBV coinfection. For information on the HBV-related use of lamivudine and tenofovir disoproxil fumarate, please refer to the HBV section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV and the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children with and Exposed to HIV.

What should I tell my health care provider before taking Cimduo?What should I tell my health care provider before taking Cimduo?

What should I tell my health care provider before taking Cimduo?

Before taking Cimduo, tell your health care provider:

• If you are allergic to any of the HIV medicines in Cimduo (lamivudine and tenofovir disoproxil fumarate) or any other medicines.
• If you have liver problems, including HBV infection or HCV infection.
• If you have kidney problems, including end-stage renal disease (ESRD) that requires dialysis.
• If you have bone problems, including a history of broken bones.
• If you have any other medical conditions.
• If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Cimduo during pregnancy. For more information on the use of Cimduo during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States.
• If you are breast/chestfeeding or plan to breast/chestfeed. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk.
• If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the HIVinfo HIV and Birth Control infographic.
• About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Cimduo may affect the way other medicines or products work, and other medicines or products may affect how Cimduo works. Taking Cimduo together with certain medicines or products may cause serious side effects.

How should I take Cimduo?How should I take Cimduo?

How should I take Cimduo?

Cimduo comes in tablet form. Each tablet contains:

• 300 mg lamivudine
• 300 mg tenofovir disoproxil fumarate

Take Cimduo according to your health care provider’s instructions. Do not miss a dose of Cimduo, and do not change your dose or stop taking Cimduo without first talking with your health care provider.

Take Cimduo by mouth with or without food.

Always take Cimduo in combination with other HIV medicines.

If you have taken too much Cimduo, contact your health care provider or local poison control center (1-800-222-1222 or online) right away, or go to the nearest hospital emergency room.

For more information on how to take Cimduo, see the FDA drug label.

What should I do if I forget a dose?What should I do if I forget a dose?

What should I do if I forget a dose?

If you miss a dose of Cimduo, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can Cimduo cause?What side effects can Cimduo cause?

What side effects can Cimduo cause?

Cimduo may cause side effects. Some side effects of Cimduo can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of Cimduo include:

• Inflammation of the pancreas (pancreatitis) in some children. Contact your health care provider right away if your child develops signs and symptoms of pancreatitis, including severe pain in the upper stomach/abdominal area, with or without nausea and vomiting.
• Bone problems, including bone pain, or softening or thinning of the bones (osteopenia), which may lead to fractures.
• Changes in your immune system (called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
• Changes in body fat (lipodystrophy syndrome).

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Cimduo. To learn more about possible side effects of Cimduo, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should Cimduo be stored?How should Cimduo be stored?

How should Cimduo be stored?

• Store Cimduo at room temperature, 68°F to 77°F (20°C to 25°C).
• Keep Cimduo in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
• Do not use Cimduo if the original seal over the container opening is broken or missing.
• Throw away Cimduo that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
• Keep Cimduo and all medicines out of reach of children.

Where can I find more information about Cimduo?Where can I find more information about Cimduo?

Where can I find more information about Cimduo?

• For more information on the use of Cimduo in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
• Recommendations on the use of Cimduo in people with HIV and HBV, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV and the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children with and Exposed to HIV.
• This Patient Version drug summary is based on the following FDA label(s): Tablet. The Patient Information section includes information for people taking Cimduo.
• The American Hospital Formulary Service (AHFS) Patient Medication Information for lamivudine and tenofovir available from MedlinePlus.
• Cimduo-related research studies, from ClinicalTrials.gov. (The ClinicalTrials.gov search can be modified so that you can get results that better match your interests.)
• A list of FDA-approved HIV medicines, from HIVinfo.