Drug information

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Brand Name
Epzicom (brand product discontinued)
Other Names
ABC / 3TC, abacavir sulfate / lamivudine
Drug Class
Combination Drugs
Nucleoside Reverse Transcriptase Inhibitor (abacavir, lamivudine)
 

What are the most important things to know about abacavir/lamivudine?What are the most important things to know about abacavir/lamivudine?

What are the most important things to know about abacavir/lamivudine?

Abacavir/lamivudine can cause serious, life-threatening side effects. These include allergic reactions, a buildup of lactic acid in the blood (lactic acidosis), and liver problems.

Abacavir/lamivudine contains abacavir, an HIV medicine. People who take abacavir-containing products, including abacavir/lamivudine, may have a serious allergic reaction (hypersensitivity reaction) that can cause death. Your risk of this allergic reaction is much higher if you have a gene variation called HLA-B*5701. Your health care provider can determine if you have this gene variation with a blood test.

If you get a symptom from two or more of the following groups while taking abacavir/lamivudine, contact your health care provider right away to find out if you should stop taking abacavir/lamivudine.

  • Group 1 Symptoms: Fever
  • Group 2 Symptoms: Rash
  • Group 3 Symptoms: Nausea, vomiting, diarrhea, stomach area (abdominal) pain
  • Group 4 Symptoms: General ill feeling, extreme tiredness, or achiness
  • Group 5 Symptoms: Shortness of breath, cough, sore throat

Your pharmacist will give you a Warning Card with a list of these symptoms. Carry this Warning Card with you at all times.

If you stop taking abacavir/lamivudine because of an allergic reaction, never take abacavir/lamivudine or any other abacavir-containing medicine again. If you take abacavir/lamivudine or any other abacavir-containing medicine again after you have had an allergic reaction, within hours you may get life-threatening symptoms that may include very low blood pressure or death.

If you stop taking abacavir/lamivudine for any other reason, even for a few days, and you are not allergic to abacavir/lamivudine, talk with your health care provider before taking it again. Taking abacavir/lamivudine again can cause a serious allergic or life-threatening reaction, even if you never had an allergic reaction to it before. If your health care provider tells you that you can take abacavir/lamivudine again, start taking it when you are around medical help or people who can call a health care provider if you need one.

Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:

  • Weakness or tiredness
  • Unusual muscle pain
  • Shortness of breath or fast breathing
  • Stomach pain with nausea and vomiting
  • Cold or blue hands and feet
  • Dizziness or lightheadedness
  • Fast or abnormal heartbeat

Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:

  • Yellowing of your skin or the whites of your eyes (jaundice)
  • Dark-colored urine
  • Light-colored bowel movements
  • Loss of appetite for several days or longer
  • Nausea or vomiting
  • Pain, aching, or tenderness on the right side of your stomach/abdominal area
  • Itching

If you have both HIV and hepatitis B virus infection (HBV) and take abacavir/lamivudine, the hepatitis B virus can change (mutate) during your treatment with abacavir/lamivudine and become harder to treat (resistant). Also, your HBV infection may get much worse (flare up) if you stop taking abacavir/lamivudine. Do not stop taking abacavir/lamivudine without first talking to your health care provider.

While taking abacavir/lamivudine, it is important to keep all of your appointments with your health care provider.

What is abacavir/lamivudine?What is abacavir/lamivudine?

What is abacavir/lamivudine?

Abacavir/lamivudine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and in children who weigh at least 55 lb (25 kg). Abacavir/lamivudine is always used in combination with other HIV medicines. 

Abacavir/lamivudine contains two different medicines: abacavir and lamivudine.

For more information on the use of abacavir/lamivudine in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.

HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.

What should I tell my health care provider before taking abacavir/lamivudine?What should I tell my health care provider before taking abacavir/lamivudine?

What should I tell my health care provider before taking abacavir/lamivudine?

Before taking abacavir/lamivudine, tell your health care provider:

  • If you are allergic to either of the HIV medicines in abacavir/lamivudine (abacavir or lamivudine) or any other medicines.
  • If you have been tested and know whether you have a particular gene variation called HLA-B*5701.
  • If you have or have had liver problems, including hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV).
  • If you have kidney problems.
  • If you have heart problems; smoke; or have diseases that increase your risk of heart disease, such as high blood pressure, high cholesterol, or diabetes.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking abacavir/lamivudine during pregnancy. For more information on the use of abacavir/lamivudine during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States.
  • If you are breast/chestfeeding or plan to breast/chestfeed. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk.
  • If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the HIVinfo HIV and Birth Control infographic.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Abacavir/lamivudine may affect the way other medicines or products work, and other medicines or products may affect how abacavir/lamivudine works. Taking abacavir/lamivudine together with certain medicines or products may cause serious side effects.

How should I take abacavir/lamivudine?How should I take abacavir/lamivudine?

How should I take abacavir/lamivudine?

Abacavir/lamivudine comes in tablet form. Each tablet contains:

Take abacavir/lamivudine according to your health care provider’s instructions. Do not miss a dose of abacavir/lamivudine, and do not change your dose or stop taking abacavir/lamivudine without first talking with your health care provider.

Take abacavir/lamivudine by mouth with or without food. Tell your health care provider if your child has trouble swallowing abacavir/lamivudine tablets.

Always take abacavir/lamivudine in combination with other HIV medicines.

If you have taken too much abacavir/lamivudine, contact your health care provider or local poison control center (1-800-222-1222 or online) right away, or go to the nearest hospital emergency room.

For more information on how to take abacavir/lamivudine, see the FDA drug label.

What should I do if I forget a dose?What should I do if I forget a dose?

What should I do if I forget a dose?

If you miss a dose of abacavir/lamivudine, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can abacavir/lamivudine cause?What side effects can abacavir/lamivudine cause?

What side effects can abacavir/lamivudine cause?

Abacavir/lamivudine may cause side effects. Some side effects of abacavir/lamivudine can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of abacavir/lamivudine include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of abacavir/lamivudine. To learn more about possible side effects of abacavir/lamivudine, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should abacavir/lamivudine be stored?How should abacavir/lamivudine be stored?

How should abacavir/lamivudine be stored?

  • Store abacavir/lamivudine at room temperature, 77°F (25°C).
  • Keep abacavir/lamivudine in the container that it came in and keep the container tightly closed.
  • Do not use abacavir/lamivudine if the original seal over the container opening is broken or missing.
  • Throw away abacavir/lamivudine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep abacavir/lamivudine and all medicines out of reach of children.

Where can I find more information about abacavir/lamivudine?Where can I find more information about abacavir/lamivudine?

Where can I find more information about abacavir/lamivudine?

Manufacturer Information

Epzicom brand products are discontinued. For manufacturer information on a generic abacavir/lamivudine product, please refer to the generic drug label or the manufacturer’s website.

 

Last Reviewed: March 21, 2024