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Clinical Guidelines

The federally approved clinical practice guidelines for HIV/AIDS are developed by panels of experts in HIV care. More information about the panels can be found in each set of guidelines. 

The recommendations in these guidelines represent the current, evidence-based consensus of the U.S. Department of Health and Human Services (HHS) HIV Clinical Guidelines Panels to support clinical care for people with HIV in the United States. These guidelines are not federal mandates.

The guidelines were updated to comply with Executive Orders.

Search Guidelines

  • Perinatal HIV Clinical Guidelines (93)
  • HIV Clinical Guidelines: Pediatric ARV (86)
  • HIV Clinical Guidelines: Adult and Adolescent ARV (67)
  • HIV Clinical Guidelines: Pediatric Opportunistic Infections (44)
  • HIV Clinical Guidelines: Adult and Adolescent Opportunistic Infections (40)
  • Guidance for Caring for People With HIV Displaced by Disasters (4)

Federally Approved Clinical Practice Guidelines for HIV/AIDS

HIV Clinical Guidelines: Adult and Adolescent ARV
Updated: September 25, 2025
HIV Clinical Guidelines: Adult and Adolescent Opportunistic Infections
Updated: March 16, 2026
HIV Clinical Guidelines: Pediatric ARV
Updated: September 30, 2025
HIV Clinical Guidelines: Pediatric Opportunistic Infections
Updated: February 26, 2026
Perinatal HIV Clinical Guidelines
Updated: June 12, 2025
Guidance for Caring for People With HIV Displaced by Disasters
Updated: October 11, 2024
Archived Guidelines

Centers for Disease Control (CDC) Guideline Reports

Pre-exposure Prophylaxis (PrEP)

Pre-exposure Prophylaxis (PrEP)

Injectable Lenacapavir as PrEP

Injectable Lenacapavir as PrEP

Occupational Postexposure Prophylaxis (PEP)

Occupational Post-exposure Prophylaxis (PEP)

Nonoccupational Post-exposure Prophylaxis (nPEP)

Nonoccupational Post-exposure Prophylaxis (nPEP)

Prevention with Persons with HIV

Prevention With Persons With HIV

Laboratory Testing

Laboratory Testing

Hormonal Contraception

Hormonal Contraception

HIV Counseling, Testing, and Referral

HIV Counseling, Testing, and Referral

Latest News

More News
Guideline
Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV
February 25, 2026
Guideline
Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV
December 22, 2025
Guideline
The HHS Panel on Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV is Accepting Nominations for Scientific/Clinical Members
December 11, 2025

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