Management of Infants Born to People with HIV Infection
Initial Postnatal Management of the Neonate Exposed to HIV
Panel's Recommendations |
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Rating of Recommendations: A = Strong; B = Moderate; C = Optional Rating of Evidence: I = One or more randomized trials with clinical outcomes and/or validated laboratory endpoints; II = One or more well-designed, nonrandomized trials or observational cohort studies with long-term clinical outcomes; III = Expert opinion |
Postnatal Management of the Neonate Exposed to HIV
Following birth, infants exposed to HIV should have a detailed physical examination, and a thorough maternal health history should be obtained. With pregnancies impacted by HIV, there may be coinfections with other pathogens that can be transmitted during pregnancy and the birthing process, such as cytomegalovirus (CMV), Zika virus, herpes simplex virus, hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis, toxoplasmosis, and tuberculosis. Infants perinatally exposed to such coinfections should undergo appropriate evaluation to exclude the possibility of transmission of additional infectious agents. The routine primary immunization schedule for children should be followed for infants perinatally exposed to HIV. One study examining humoral response to routine vaccination in infants who were exposed to HIV but uninfected (HEU) demonstrated robust antibody responses to vaccine antigens to support this recommendation.1 However, the immunization schedule may need to be modified for infants with confirmed HIV infection (see the Pediatric Opportunistic Infections Guidelines for more information).
No evidence is available to enable the Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission to assess whether any changes in routine bathing practices or timing of circumcision are indicated for newborns with perinatal HIV exposure.
Antiretroviral Prophylaxis and Presumptive HIV Therapy in Infants
All newborns exposed to HIV should receive appropriate antiretroviral (ARV) drugs as soon as possible, preferably within 6 hours after birth (see Antiretroviral Management of Infants With In Utero, Intrapartum, or Breastfeeding Exposure to HIV). Providers should instruct caregivers on how to measure and administer ARV drugs correctly, provide access to medications after discharge, explain the importance of adherence, and suggest strategies for avoiding missed doses (see Adherence to Antiretroviral Therapy in Children and Adolescents With HIV ).
Based on existing safety data, longitudinal laboratory monitoring for adverse events is not needed in otherwise healthy infants receiving currently recommended ARV drugs used for prophylaxis unless administration occurs beyond 6 weeks of life. The American Academy of Pediatrics recommends periodic monitoring of hematologic and liver toxicity in breastfeeding infants receiving ARV prophylaxis with nevirapine (NVP) beyond this period and for extended durations.2 See Safety of Antiretroviral Drugs Used for Infant Prophylaxis in Antiretroviral Management of Infants With In Utero, Intrapartum, or Breastfeeding Exposure to HIV.
Hematologic Toxicity
Older studies have shown that anemia is the primary hematologic complication in neonates who received a 6‑week postnatal prophylaxis regimen with zidovudine (ZDV).3 Combination ARV regimens are associated with an elevated risk of toxicity compared with single agents, but the three-drug regimens currently recommended for presumptive treatment (e.g., NVP/ZDV/lamivudine [3TC] or raltegravir [RAL]/ZDV/3TC) appear very safe when used for 6 or fewer weeks. For more information, see Combination ARV Regimens in Antiretroviral Management of Infants With In Utero, Intrapartum, or Breastfeeding Exposure to HIV.
Infants who are found to have hematologic abnormalities may need to discontinue ARV drugs. Clinicians should base the decision to discontinue ARV drugs on the individual needs of the patient. Considerations include the extent of the abnormality, whether related symptoms are present, the duration of ARV drugs received by the infant, and the risk of HIV infection (as assessed by maternal history of ARV drugs, viral load near birth, and mode of birth). A 2-week ZDV neonatal regimen is recommended in situations where there is a low risk of perinatal HIV transmission (see specific criteria in Table 11. Antiretroviral Management for Infants With In Utero or Intrapartum Exposure to HIV in Antiretroviral Management of Infants With In Utero, Intrapartum, or Breastfeeding Exposure to HIV).4 The shorter ZDV regimen may mitigate the risk of anemia in infants who are HEU.
Hyperbilirubinemia
The primary toxicity of concern with the use of RAL in the neonatal period has been the potential displacement of unconjugated bilirubin from albumin binding sites. However, at recommended dosing, RAL appears safe. RAL is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, the same enzyme responsible for the elimination of bilirubin; UGT enzyme activity is low at birth, and RAL elimination is prolonged in neonates. In addition, RAL binds albumin, raising a theoretical concern that displacement of bilirubin could lead to hyperbilirubinemia. However, in vitro studies suggest RAL is safe at the drug exposures achieved for treatment.5 IMPAACT P1110, the single-arm regulatory Phase 1/2 trial that established dosing for RAL, evaluated safety in 52 infants of 34 weeks gestational age and older; no adverse events were attributed to RAL, and no bilirubin levels exceeded 16 mg/dL.6
Prophylaxis Against Pneumocystis jirovecii Pneumonia
To prevent Pneumocystis jirovecii pneumonia, all high-risk infants born to people with HIV should begin trimethoprim-sulfamethoxazole prophylaxis at age 4 to 6 weeks, unless adequate virologic test information exists to presumptively exclude HIV infection (see the Pneumocystis jirovecii Pneumonia section of the Pediatric Opportunistic Infections Guidelines).7 With appropriate follow‑up to support the recommended diagnostic testing schedule, most infants with perinatal HIV exposure do not require trimethoprim-sulfamethoxazole prophylaxis because HIV can be presumptively excluded by the time their postnatal ARV regimen is completed (see Diagnosis of HIV Infection in Infants and Children).
Testing for Viral Coinfections in the Infant
The prevalence of congenital CMV (cCMV) is higher in infants with perinatal exposure to HIV than in the general population.8-13 Screening for cCMV is recommended in the first 21 days of life. Early diagnosis allows for appropriate monitoring and antiviral intervention with (val)ganciclovir, which improves clinical outcomes for associated comorbidities, including sensorineural hearing loss. The Pediatric Opportunistic Infection Guidelines recommend testing for cCMV in urine and/or saliva using a polymerase chain reaction assay, and a routine newborn audiologic evaluation. For infants diagnosed with cCMV, longitudinal audiologic follow-up and neurodevelopmental assessments are recommended (see Cytomegalovirus).14 In certain states, universal newborn screening for cCMV is recommended using dried blood spots. This test currently serves as an adjunct to urinary and salivary testing for CMV pending further validation.
HCV screening with an anti-HCV antibody test is recommended for allduring each pregnancy.15,16 The Centers for Disease Control and Prevention (CDC) recommends HCV testing for all infants and children perinatally exposed to current or probable HCV infection. Infants with perinatal exposure to HCV should receive a nucleic acid test (NAT) for HCV RNA at age 2 to 6 months to identify children in whom chronic HCV infection might develop.17 Parents or caregivers should receive counseling about the need for testing and follow-up (see Hepatitis C Virus/HIV Coinfection). Infants with detectable HCV RNA should be managed in consultation with a health care provider who has expertise in pediatric HCV management. Infants with an undetectable HCV RNA result do not require further follow-up unless clinically warranted.18
It is recommended that HBV screening for hepatitis B surface antigen (HBsAg) occur for all during each pregnancy, preferably in the first trimester, regardless of vaccination status or history of testing (see Hepatitis B Virus/HIV Coinfection).19 The CDC recommends that infants perinatally exposed to HBsAg be tested for HBsAg. In the context of a positive maternal HBsAg screening, all infants including those with perinatal HIV exposure, should receive hepatitis B immune globulin and the first dose of the HBV vaccine series as soon as possible, preferably within 12 hours after birth, followed by the routine HBV vaccine series. Post-vaccination serologic testing for HBV should be performed between 9 and 12 months of age (see Evaluating and Managing Infants Who Were Exposed to HIV in Hepatitis B Virus/HIV Coinfection). Infants with detectable HBV DNA should be managed in consultation with a health care provider with expertise in pediatric HBV management.
HIV Testing of the Infant
All infants who are perinatally exposed to HIV require diagnostic testing using NATs (e.g., HIV RNA or HIV DNA assays) to diagnose or exclude HIV infection. For a detailed discussion of HIV testing, including types of tests and the recommended HIV testing schedule, see Table 13. Recommended Virologic Testing Schedules for Infants With Perinatal and Breastfeeding Exposure to HIV in Diagnosis of HIV Infection in Infants and Children.
Infant Feeding Practices and Risk of HIV Transmission
Evidence-based, patient-centered counseling should be provided to support shared decision-making about infant feeding prior to conception or as early as possible in pregnancy with HIV. Plans for infant feeding should be reviewed throughout pregnancy and again after birth. At postnatal visits, it is important to discuss infant feeding to assess feeding practices, identify barriers, and provide supports for the appropriate implementation of their chosen method (see Preventing HIV Transmission During Infant Feeding). For information on ARV prophylaxis duration and HIV screening frequency for breastfeeding infants, see Antiretroviral Management of Infants With In Utero, Intrapartum, or Breastfeeding Exposure to HIV, Pregnancy and Postpartum HIV Testing and Identification of Perinatal and Postnatal HIV Exposure, and Diagnosis of HIV Infection in Infants and Children.
References
- Smith C, Huo Y, Patel K, et al. Immunologic and virologic factors associated with hospitalization in human immunodeficiency virus-exposed, uninfected infants in the United States. Clin Infect Dis. 2021;73(6):1089-1096. Available at: https://pubmed.ncbi.nlm.nih.gov/34157096.
- Abuogi L, Noble L, Smith C, et al. Infant feeding for persons living with and at risk for HIV in the United States: clinical report. Pediatrics. 2024. Available at: https://pubmed.ncbi.nlm.nih.gov/38766700.
- Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994;331(18):1173-1180. Available at: https://pubmed.ncbi.nlm.nih.gov/7935654.
- Ferguson W, Goode M, Walsh A, et al. Evaluation of 4 weeks’ neonatal antiretroviral prophylaxis as a component of a prevention of mother-to-child transmission program in a resource-rich setting. Pediatr Infect Dis J. 2011;30(5):408-412. Available at: https://pubmed.ncbi.nlm.nih.gov/21266939.
- Clarke DF, Wong RJ, Wenning L, et al. Raltegravir in vitro effect on bilirubin binding. Pediatr Infect Dis J. 2013;32(9):978-980. Available at: https://pubmed.ncbi.nlm.nih.gov/23470680.
- Clarke DF, Acosta EP, Cababasay M, et al. Raltegravir (RAL) in neonates: dosing, pharmacokinetics (PK), and safety in HIV-1-exposed neonates at risk of infection (IMPAACT P1110). J Acquir Immune Defic Syndr. 2020;84(1):70-77. Available at: https://pubmed.ncbi.nlm.nih.gov/31913995.
- Mofenson LM, Brady MT, Danner SP, et al. Guidelines for the prevention and treatment of opportunistic infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. MMWR Recomm Rep. 2009;58(RR-11):1-166. Available at: https://pubmed.ncbi.nlm.nih.gov/19730409.
- Dollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol. 2007;17(5):355-363. Available at: https://pubmed.ncbi.nlm.nih.gov/17542052.
- Gantt S, Leister E, Jacobsen DL, et al. Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy. J Med Virol. 2016;88(6):1051-1058. Available at: https://pubmed.ncbi.nlm.nih.gov/26519647.
- Guibert G, Warszawski J, Le Chenadec J, et al. Decreased risk of congenital cytomegalovirus infection in children born to HIV-1-infected mothers in the era of highly active antiretroviral therapy. Clin Infect Dis. 2009;48(11):1516-1525. Available at: https://pubmed.ncbi.nlm.nih.gov/19388872.
- Kovacs A, Schluchter M, Easley K, et al. Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med. 1999;341(2):77-84. Available at: https://pubmed.ncbi.nlm.nih.gov/10395631.
- Manicklal S, van Niekerk AM, Kroon SM, et al. Birth prevalence of congenital cytomegalovirus among infants of HIV-infected women on prenatal antiretroviral prophylaxis in South Africa. Clin Infect Dis. 2014;58(10):1467-1472. Available at: https://pubmed.ncbi.nlm.nih.gov/24567248.
- Smith C, Silveira L, Crotteau M, et al. Congenital co-infections among HIV-exposed infants born to mothers on antiretroviral treatment in the United States. Front Pediatr. 2022;10:894627. Available at: https://pubmed.ncbi.nlm.nih.gov/35783327.
- Panel on Opportunistic Infections Among HIV-Exposed and HIV-Infected Children. Guidelines for the prevention and treatment of opportunistic infections in children with and exposed to HIV. 2023. Available at: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-pediatric-opportunistic-infections/whats-new?view=full.
- Centers for Disease Control and Prevention. Recommended testing sequence for identifying current hepatitis C virus (HCV) infection. 2023. Available at: https://www.cdc.gov/hepatitis/hcv/pdfs/hcv_flow.pdf.
- Schillie S, Wester C, Osborne M, et al. CDC recommendations for hepatitis C screening among adults–United States. MMWR Recomm Rep 2020;69(No. RR-2):1–17. Available at: https://www.cdc.gov/mmwr/volumes/69/rr/rr6902a1.htm.
- Polywka S, Pembrey L, Tovo PA, Newell ML. Accuracy of HCV-RNA PCR tests for diagnosis or exclusion of vertically acquired HCV infection. J Med Virol. 2006;78(2):305-310. Available at: https://pubmed.ncbi.nlm.nih.gov/16372293.
- Panagiotakopoulos L, Sandul AL, DHSc, et al. CDC recommendations for hepatitis C testing among perinatally exposed infants and children–United States, 2023. MMWR Recomm Rep. 2023;72(4):1-21. Available at: https://pubmed.ncbi.nlm.nih.gov/37906518.
- Conners EE, Panagiotakopoulos L, Hofmeister MG, et al. Screening and testing for hepatitis B virus infection: CDC recommendations–United States, 2023. MMWR Recomm Rep. 2023;72(1):1-25. Available at: https://pubmed.ncbi.nlm.nih.gov/36893044.
Management of Infants Born to People with HIV Infection
Initial Postnatal Management of the Neonate Exposed to HIV
Panel's Recommendations |
---|
|
Rating of Recommendations: A = Strong; B = Moderate; C = Optional Rating of Evidence: I = One or more randomized trials with clinical outcomes and/or validated laboratory endpoints; II = One or more well-designed, nonrandomized trials or observational cohort studies with long-term clinical outcomes; III = Expert opinion |
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