Integration

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The fourth of seven steps in the HIV life cycle. Once inside the host CD4 cell nucleus, HIV releases integrase, an HIV enzyme. HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host cell.

Related Term(s)
Integrase
Integrase Strand Transfer Inhibitor (INSTI)
Life Cycle
Provirus
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Integration is the step in the HIV life cycle where HIV uses integrase to insert its viral DNA into the DNA of the host cell.
Life cycle of HIV: 1) cell binding, 2) fusion, 3) reverse transcription, 4) Integration, 5) replication, 6) assembly, and 7) budding out.

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