Drug information

What is Vosevi?What is Vosevi?

What is Vosevi?

Vosevi is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic hepatitis C virus infection (HCV) in adults who meet certain requirements, as determined by a health care provider.

HCV can be an opportunistic infection (OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? fact sheet.

To learn how HIV and HCV are connected, read the HIVinfo HIV and Hepatitis C fact sheet. The fact sheet includes information about how HCV is spread, symptoms of HCV, and treatment options.

How is Vosevi used in people with HIV?How is Vosevi used in people with HIV?

How is Vosevi used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV reference the AASLD-IDSA HCV Guidance, which includes recommendations on the use of Vosevi to treat HCV in people with HIV.

The recommended uses may not always be consistent with FDA-approved uses of Vosevi. See the AASLD-IDSA HCV Guidance for complete information on recommended uses of Vosevi in adults with HIV. Vosevi may have other recommended uses not listed above.

What should I tell my health care provider before taking Vosevi?What should I tell my health care provider before taking Vosevi?

What should I tell my health care provider before taking Vosevi?

Before taking Vosevi, tell your health care provider:

  • If you are allergic to any of the medicines in Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) or any other medicines.
  • About any medical conditions you have or have had, especially:
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
  • If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Vosevi during pregnancy. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV may include other recommendations on the use of Vosevi during pregnancy. Please refer to these guidelines for additional information.
  • If you are breastfeeding or plan to breastfeed. For mothers with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. Mothers with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk. Although most medicines are safe to use while breastfeeding, some medicines should be avoided. Always let your health care provider know about all the medicines and supplements you are taking before you start breastfeeding.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (including St. John's wort) you are taking or plan to take. Vosevi may interact with other medicines or supplements. For a list of medicines and supplements that may interact with Vosevi, see the drug label or ask your health care provider or pharmacist. You can also look up potential interactions between your HCV medicine and other drugs using the HEP Drug Interaction Checker online.

How should I take Vosevi?How should I take Vosevi?

How should I take Vosevi?

Take Vosevi according to your health care provider’s instructions. Your health care provider will tell you how much Vosevi to take and when to take it.

It is important to complete the full prescribed course of treatment with Vosevi, even if you begin to feel better. If you stop using Vosevi too soon or skip doses, your infection may not be fully treated, and the virus may become harder to treat (resistant).

Before you start Vosevi and each time you get a refill, read any printed information that comes with your medicine.

What side effects can Vosevi cause?What side effects can Vosevi cause?

What side effects can Vosevi cause?

Vosevi may cause side effects that can be mild or serious. To learn about possible side effects of Vosevi, see the FDA drug label or talk to your health care provider or pharmacist. Tell your health care professional if you have any side effect that bothers you or that does not go away. Your health care professional may be able to tell you about ways to prevent or reduce some side effects.

You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should Vosevi be stored?How should Vosevi be stored?

How should Vosevi be stored?

  • Store Vosevi below 86°F (30°C).
  • Keep Vosevi in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. Do not eat the desiccant. The desiccant protects the medicine from moisture.
  • Do not use Vosevi if the original seal over the container opening is broken or missing.
  • Throw away Vosevi that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep Vosevi and all medicines out of reach of children.

Where can I find more information about Vosevi?Where can I find more information about Vosevi?

Where can I find more information about Vosevi?

Last Reviewed: August 18, 2026