Drug Database: Elvitegravir / Cobicistat / Emtricitabine / Tenofovir Disoproxil Fumarate

What is Stribild?What is Stribild?

What is Stribild?

Stribild is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children who weigh at least 77 lb (35 kg) and meet certain requirements, as determined by a health care provider.

Stribild is a complete HIV treatment regimen and should not be used with other HIV medicines

Stribild contains four different medicines: elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate.

For more information on the use of Stribild in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.

HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.

What should I tell my health care provider before taking Stribild?What should I tell my health care provider before taking Stribild?

What should I tell my health care provider before taking Stribild?

Before taking Stribild, tell your health care provider:

• If you are allergic to any of the HIV medicines in Stribild (elvitegravir, cobicistat, emtricitabine, or tenofovir disoproxil fumarate) or any other medicines.
• If you have liver problems, including hepatitis B virus infection (HBV).
• If you have kidney problems.
• If you have bone problems.
• If you have any other medical conditions.
• If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Stribild during pregnancy. For more information on the use of Stribild during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States.
• If you are breast/chestfeeding or plan to breast/chestfeed. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk. Although most medicines are safe to use while breast/chestfeeding, some medicines should be avoided. Always let your health care provider know about all the medicines and supplements you are using before you start breast/chestfeeding.
• If you are using hormone-based birth control (such as pills, implants, or vaginal rings). Your health care provider may recommend that you use additional or alternative forms of birth control while taking Stribild. For more information about using birth control and HIV medicines at the same time, view the HIVinfo HIV and Birth Control infographic.
• About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (including St. John's wort) you are taking or plan to take. Stribild may affect the way other medicines or products work, and other medicines or products may affect how Stribild works. Taking Stribild together with certain medicines or products may cause serious, life-threatening side effects.

How should I take Stribild?How should I take Stribild?

How should I take Stribild?

Stribild comes in tablet form. Each tablet contains:

• 150 mg elvitegravir
• 150 mg cobicistat
• 200 mg emtricitabine
• 300 mg tenofovir disoproxil fumarate

Take Stribild according to your health care provider’s instructions. Do not miss a dose of Stribild, and do not change your dose or stop taking Stribild without first talking with your health care provider.

Take Stribild by mouth and with food. Do not take Stribild with other HIV medicines.

If you are taking any other medicines, supplements, antacids, or laxatives that contain magnesium, aluminum, calcium, iron, or zinc, take them at least 2 hours before or after you take Stribild.

If you have taken too much Stribild, contact your health care provider or local poison control center (1-800-222-1222 or online) right away, or go to the nearest hospital emergency room.

For more information on how to take Stribild, see the FDA drug label.

What should I do if I forget a dose?What should I do if I forget a dose?

What should I do if I forget a dose?

If you miss a dose of Stribild, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can Stribild cause?What side effects can Stribild cause?

What side effects can Stribild cause?

Stribild may cause side effects. Some side effects can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of Stribild include:

• Bone problems, including bone pain, or softening, or thinning of the bones (osteopenia), which may lead to fractures.
• Changes in your immune system (called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Stribild. To learn more about possible side effects of Stribild, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should Stribild be stored?How should Stribild be stored?

How should Stribild be stored?

• Store Stribild at room temperature, 68°F to 77°F (20°C to 25°C).
• Keep Stribild in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
• Do not use Stribild if the original seal over the container opening is broken or missing.
• Throw away Stribild that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
• Keep Stribild and all medicines out of reach of children.

Where can I find more information about Stribild?Where can I find more information about Stribild?

Where can I find more information about Stribild?

• For more information on the use of Stribild in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
• This Patient Version drug summary is based on the following FDA label(s): Tablet. The Patient Package Insert includes information for people taking Stribild.
• The American Hospital Formulary Service (AHFS) Patient Medication Information for elvitegravir, cobicistat, emtricitabine, and tenofovir available from MedlinePlus.
• Stribild-related research studies, from ClinicalTrials.gov. (The ClinicalTrials.gov search can be modified so that you can get results that better match your interests.)
• A list of FDA-approved HIV medicines, from HIVinfo.