Fixed-Dose Combinations

Appendix A, Table 1. Antiretrovirals Available in Fixed-Dose Combination Tablets

Appendix A, Table 1. Antiretrovirals Available in Fixed-Dose Combination Tablets
Brand Name by Class NRTIs NNRTIs INSTIs PIs PK Enhancers
ABC 3TC ZDV FTC TDF TAFa  DOR EFV RPV BICa DTG EVGa ATV DRV LPVb COBI RTV
NRTI
Cimduo   X     X                        
Combivir, Generic   X X                            
Descovy       X    X                      
Epzicom, Generic  X  X                              
Temixys    X                            
Trizivir, Generic  X  X  X                            
Truvada        X  X                        
NRTI/NNRTI
Atripla        X  X      X                  
Complera        X  X        X                
Delstrigo                            
Odefsey        X    X      X                
Symfi or Symfi Lo    X      X      X                  
NRTI/INSTI
Biktarvy        X    X        X              
Dovato   X                  X            
Triumeq  X  X                  X            
NNRTI/INSTI
Juluca                  X    X            
NRTI/INSTI/COBI
Genvoya        X    X            X        X  
Stribild        X  X              X        X  
NRTI/PI/COBI
Symtuza        X    X                X    X  
PI/COBI
Evotaz                          X      X  
Prezcobix                            X    X  
PI/RTV
Kaletra                              X    X
a TAF, BIC, and EVG are only available in FDC tablets. However, TAF 25 mg tablets (Vemlidy) are FDA-approved for treatment of HBV. In select circumstances, TAF might be used as one component of a combination ARV regimen, with dosing recommendations similar to those for Descovy.

b LPV is only available in FDC tablets or solution.

Key to Acronyms: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; ATV = atazanavir; BIC = bictegravir; COBI = cobicistat; DOR = doravirine; DRV = darunavir; DTG = dolutegravir; EFV = efavirenz; EVG = elvitegravir; FDA = Food and Drug Administration; FDC = fixed-dose combination; FTC = emtricitabine; HBV = hepatitis B virus; LPV = lopinavir; LPV/r = lopinavir; NNRTI = non-nucleoside reverse transcriptase inhibitor; NRTI = nucleoside and nucleotide reverse transcriptase inhibitor; PI = protease inhibitor; PK = pharmacokinetic; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine

Fixed-Dose Combinations

Appendix A, Table 1. Antiretrovirals Available in Fixed-Dose Combination Tablets

Appendix A, Table 1. Antiretrovirals Available in Fixed-Dose Combination Tablets
Brand Name by Class NRTIs NNRTIs INSTIs PIs PK Enhancers
ABC 3TC ZDV FTC TDF TAFa  DOR EFV RPV BICa DTG EVGa ATV DRV LPVb COBI RTV
NRTI
Cimduo   X     X                        
Combivir, Generic   X X                            
Descovy       X    X                      
Epzicom, Generic  X  X                              
Temixys    X                            
Trizivir, Generic  X  X  X                            
Truvada        X  X                        
NRTI/NNRTI
Atripla        X  X      X                  
Complera        X  X        X                
Delstrigo                            
Odefsey        X    X      X                
Symfi or Symfi Lo    X      X      X                  
NRTI/INSTI
Biktarvy        X    X        X              
Dovato   X                  X            
Triumeq  X  X                  X            
NNRTI/INSTI
Juluca                  X    X            
NRTI/INSTI/COBI
Genvoya        X    X            X        X  
Stribild        X  X              X        X  
NRTI/PI/COBI
Symtuza        X    X                X    X  
PI/COBI
Evotaz                          X      X  
Prezcobix                            X    X  
PI/RTV
Kaletra                              X    X
a TAF, BIC, and EVG are only available in FDC tablets. However, TAF 25 mg tablets (Vemlidy) are FDA-approved for treatment of HBV. In select circumstances, TAF might be used as one component of a combination ARV regimen, with dosing recommendations similar to those for Descovy.

b LPV is only available in FDC tablets or solution.

Key to Acronyms: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; ATV = atazanavir; BIC = bictegravir; COBI = cobicistat; DOR = doravirine; DRV = darunavir; DTG = dolutegravir; EFV = efavirenz; EVG = elvitegravir; FDA = Food and Drug Administration; FDC = fixed-dose combination; FTC = emtricitabine; HBV = hepatitis B virus; LPV = lopinavir; LPV/r = lopinavir; NNRTI = non-nucleoside reverse transcriptase inhibitor; NRTI = nucleoside and nucleotide reverse transcriptase inhibitor; PI = protease inhibitor; PK = pharmacokinetic; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine
Updated
Sep. 12, 2019
Reviewed
Sep. 12, 2019

Download Guidelines