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Appendix D: Review of Clinical Trials of Antiretroviral Interventions to Prevent Perinatal HIV Transmission

… plus single-dose nevirapine at delivery plus postpartum tenofovir disoproxil fumarate (TDF)/emtricitabine tail … . Nielsen-Saines K, et al. Tenofovir disoproxil fumarate (TDF) pharmacokinetics (PK) …

Appendix A. Drug Characteristics Tables

… Dosing Recommendation a INSTI Plus Two NRTIs Bictegravir/Tenofovir Alafenamide/Emtricitabine (BIC/TAF/FTC) Biktarvy … 300 mg One tablet PO once daily Elvitegravir/Cobicistat/Tenofovir Alafenamide/Emtricitabine (EVG/c/TAF/FTC) Genvoya … One tablet PO once daily with food Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine (EVG/c/TDF/FTC) …

Immunizations for Preventable Diseases in Adults and Adolescents With HIV

… ongoing risk factors for acquiring HBV and is not receiving tenofovir (CIII). 31 Waning immunity is typically seen in … Therapy Considerations HBV-active ART (includes tenofovir with lamivudine [3TC] or emtricitabine [FTC]) … incident HBV was similar in those taking lamivudine- or tenofovir-containing ART regimens. In another report of …

Appendix C: Drug Name Abbreviations

… RTV or r ritonavir SQV saquinavir T-20 enfuvirtide TAF tenofovir alafenamide TDF tenofovir disoproxil fumarate TFV tenofovir TFV-DP tenofovir-diphosphate TMP-SMX …

… other potentially nephrotoxic medications, including tenofovir disoproxil fumarate. 97 Periodic (e.g., weekly) …

Disseminated Mycobacterium avium Complex Disease

… of TB suggests that bictegravir (coformulated with tenofovir alafenamide and emtricitabine) might be used with … MP, et al. Fixed-dose combination bictegravir-emtricitabine-tenofovir alafenamide twice-daily for treatment of HIV …

Mycobacterium tuberculosis Infection and Disease

… = raltegravir; RTV = ritonavir; T-20 = enfuvirtide; TAF = tenofovir alafenamide; TB = tuberculosis Treatment of LTBI … = ritonavir; SC = subcutaneous; T-20 = enfuvirtide; TAF = tenofovir alafenamide; TB = tuberculosis; TDM = Therapeutic … reverse transcriptase inhibitors, including tenofovir disoproxil fumarate (TDF), tenofovir alafenamide …

Table 4. Significant Pharmacokinetic Interactions Between Drugs Used to Treat or Prevent Opportunistic Infections

… Sofosbuvir Bedaquiline Doxycycline Linezolid Rifabutin Tenofovir Chloroquine Fluconazole Mefloquine Rifampin … Rifampin. Rifapentine a See Rifapentine. See Rifapentine. Tenofovir Alafenamide Glecaprevir/Pibrentasvir See … See Sofosbuvir/Velpatasvir. See Sofosbuvir/Velpatasvir. Tenofovir Disoproxil Fumarate Rifabutin a See Rifabutin. See …

Table 5. Serious and/or Common Adverse Reactions Associated with Systemically Administered Drugs Used to Treat or Prevent Opportunistic Infections

… Infusion- or injection-related reactions Thrombocytopenia Tenofovir Disoproxil Fumarate Renal insufficiency and … Decrease in bone mineral density Nausea and vomiting Tenofovir Alafenamide Lower incidence of renal or bone toxicities than with tenofovir disoproxil fumarate Trimethoprim-Sulfamethoxazole …

Table 6. Dosing Recommendations for Drugs Used to Treat or Prevent Opportunistic Infections that Require Dosage Adjustment in Adults With Renal Insufficiency

… Levofloxacin Posaconazole Pyrazinamide Quinine Rifabutin Tenofovir Trimethoprim Valacyclovir Voriconazole … necessary. No dose adjustment necessary. Emtricitabine/ Tenofovir Alafenamide (FTC/TAF) (FDC Trade Name: Descovy) … on dialysis days, administer dose after HD. Emtricitabine/ Tenofovir Disoproxil Fumarate (FTC/TDF) (FDC Trade Name: …

Appendix A: List of Abbreviations

… SMX sulfamethoxazole TCA trichloroacetic acid TDF tenofovir disoproxil fumarate TMP trimethoprim TMP-SMX …

Table 5. Significant Drug Interactions for Drugs Used to Treat or Prevent Opportunistic Infections

… valacyclovir, valganciclovir, ganciclovir, cidofovir ARVs: tenofovir Immunosuppressive agents : mycophenolate Monitor … or ototoxic drugs Antimycobacterials : capreomycin ARVs: tenofovir Antivirals : cidofovir Caution advised. Avoid … : aminoglycosides Antivirals : foscarnet ARVs : tenofovir Nephrotoxic drugs Monitor for toxicities of these …