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What's New in the Guidelines
… Therapy During Pregnancy Bictegravir (BIC) plus tenofovir alafenamide (TAF) plus FTC (available as the … now include BIC plus TAF plus FTC  or  DTG plus (TAF or tenofovir disoproxil fumarate [TDF]) plus (FTC or 3TC). For …
Candida Infections
… but itraconazole may increase exposures and AEs from tenofovir disoproxil fumarate and tenofovir alafenamide. Most integrase strand transferase …
Pre-exposure Prophylaxis (PrEP) to Prevent HIV During Periconception, Antepartum, and Postpartum Periods
… HIV prevention option for the individual patient (AIII). Tenofovir disoproxil fumarate plus emtricitabine is … are pregnant, postpartum, or breastfeeding. 3 Combination tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) as … regarding the risk of possible hepatitis flares when tenofovir-based PrEP is stopped. 36 See Hepatitis B …
Overview
… Transfer Inhibitors (INSTIs) Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Dosing … RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate Sources: Panel on …
COVID-19
… of HIV (e.g., lopinavir/‌ritonavir, boosted darunavir, or tenofovir disoproxil fumarate/emtricitabine) have efficacy …
Recommendations for Use of Antiretroviral Drugs During Pregnancy: Overview
… with using Preferred and Alternative ARV drugs other than tenofovir disoproxil fumarate, emtricitabine, lamivudine, … especially among women and people also receiving tenofovir alafenamide (see Dolutegravir and Tenofovir Alafenamide ). 16,17 However, it is difficult to …
Initial Use of Antiretroviral Therapy During Pregnancy
… (INSTIs) dolutegravir (DTG) or bictegravir (BIC) plus a tenofovir-containing dual–‍nucleoside reverse transcriptase … Infection ) (AIII). Preferred regimens include: DTG plus (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) plus (emtricitabine [FTC] or …
Previous Experience With Antiretroviral Medications but Not Currently on Antiretroviral Therapy During Current Pregnancy
… the use of the PI darunavir boosted with ritonavir with (tenofovir alafenamide or tenofovir disoproxil fumarate)plus (emtricitabine or …
Lack of Viral Suppression While on Antiretroviral Therapy in Pregnancy
… in South Africa (2021–2023), describing treatment with tenofovir/lamivudine/DTG initiated before 18 weeks of … in pregnancy drop postpartum in South African women on tenofovir-lamivudine-dolutegravir: a prospective cohort …
Table 6. What to Start: Initial Antiretroviral Regimens During Pregnancy
… = raltegravir; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine; v/v = …
Teratogenicity
… = rilpivirine; RTV = ritonavir; T‑20 = enfuvirtide; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine For …
Hepatitis B Virus/HIV Coinfection
… administration of a HBV vaccines series (AII). Because tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), lamivudine (3TC) and … coinfection during pregnancy, an ART regimen that includes tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide …
HIV-2 and Pregnancy
… those recommended for treatment of HIV-1 during pregnancy: tenofovir disoproxil fumarate or tenofovir alafenamide plus emtricitabine (FTC) or lamivudine …
Early (Acute and Recent) HIV Infection
… for initial ART b (AIII): Dolutegravir (DTG) with (tenofovir alafenamide fumarate [TAF] or tenofovir disoproxil fumarate [TDF]) c plus (emtricitabine … infection, a regimen that includes dolutegravir (DTG) with tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide …
Hepatitis B Virus Infection
… HBV is recommended; the preferred regimen should include tenofovir (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) and either lamivudine (3TC) or …
Hepatitis C Virus Infection
… the following: Velpatasvir can increase concentrations of tenofovir disoproxil fumarate and lead to tenofovir-related renal toxicity. It is unclear at this time whether this is also the case with tenofovir alafenamide. Nevertheless, care should be taken in …
Preventing HIV Transmission During Infant Feeding
… infant. 92 NRTIs show more variability than PIs and NNRTIs. Tenofovir concentrations from tenofovir disoproxil fumarate (TDF) are very low in breast … Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk …
Herpes Simplex Virus
… . Abdool Karim SS, Abdool Karim Q, Kharsany AB, et al. Tenofovir gel for the prevention of herpes simplex virus …
Long-Term Follow-Up of Infants Exposed to Antiretroviral Drugs
… HIV transmission. 2,90 In addition, newer NRTIs, such as tenofovir, have not been associated with the same degree of … of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse … Stray KM, Park Y, Babusis D, et al. Tenofovir alafenamide (TAF) does not deplete mitochondrial …
Drug Name Abbreviations
… saquinavir SQV/r saquinavir/ritonavir T-20 enfuvirtide TAF tenofovir alafenamide TDF tenofovir disoproxil fumarate TFV tenofovir TFV-DP tenofovir diphosphate TMR temsavir TPV …