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What's New in the Guidelines
… isolated anti–hepatitis B core antibody to reflect that tenofovir-sparing regimens can also be considered with …
Candida Infections
… but itraconazole may increase exposures and AEs from tenofovir disoproxil fumarate and tenofovir alafenamide. Most integrase strand transferase …
COVID-19
… of HIV (e.g., lopinavir/‌ritonavir, boosted darunavir, or tenofovir disoproxil fumarate/emtricitabine) have efficacy …
Hepatitis B Virus Infection
… HBV is recommended; the preferred regimen should include tenofovir (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) and either lamivudine (3TC) or …
Cytomegalovirus Disease
… other potentially nephrotoxic medications, including tenofovir disoproxil fumarate. Periodic ophthalmologic …
Hepatitis B Virus Infection
… routine HBV DNA testing is not recommended. However, if a tenofovir-sparing HIV regimen is being considered, some … people with HIV/HBV coinfection (median age 41 years) on tenofovir-containing antiretroviral therapy (ART), the … yearly (AIII). Special Considerations When Initiating Tenofovir-Sparing ARV Regimens In people without a history …
Hepatitis C Virus Infection
… the following: Velpatasvir can increase concentrations of tenofovir disoproxil fumarate and lead to tenofovir-related renal toxicity. It is unclear at this time whether this is also the case with tenofovir alafenamide. Nevertheless, care should be taken in …
Herpes Simplex Virus
… . Abdool Karim SS, Abdool Karim Q, Kharsany AB, et al. Tenofovir gel for the prevention of herpes simplex virus …
Hepatitis C Virus
… DAA regimens. Additionally, the improved safety profile of tenofovir alafenamide (TAF) combined with safety data in the … HBV = hepatitis B virus; HCV = hepatitis C virus; TDF = tenofovir disoproxil fumarate A limited pre-treatment … also increase velpatasvir exposure, which in turn increases tenofovir plasma exposure particularly when administered as …
Herpes Simplex Virus
… In clinical trials, pre-exposure prophylaxis with vaginal tenofovir gel and oral tenofovir disoproxil fumarate (TDF) or with … Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the …
Immunizations for Preventable Diseases in Adults and Adolescents With HIV
… ongoing risk factors for acquiring HBV and is not receiving tenofovir (CIII). 31 Waning immunity is typically seen in … Therapy Considerations HBV-active ART (includes tenofovir with lamivudine [3TC] or emtricitabine [FTC]) … incident HBV was similar in those taking lamivudine- or tenofovir-containing ART regimens. In another report of …
Mpox
… other potentially nephrotoxic medications, including tenofovir disoproxil fumarate. 97 Periodic (e.g., weekly) …
Disseminated Mycobacterium avium Complex Disease
… of TB suggests that bictegravir (coformulated   with tenofovir alafenamide and emtricitabine) might be used with … MP, et al. Fixed-dose combination bictegravir-emtricitabine-tenofovir alafenamide twice-daily for treatment of HIV …
Mycobacterium tuberculosis Infection and Disease
… = raltegravir; RTV = ritonavir; T-20 = enfuvirtide; TAF = tenofovir alafenamide; TB = tuberculosis Treatment of LTBI … = ritonavir; SC = subcutaneous; T-20 = enfuvirtide; TAF = tenofovir alafenamide; TB = tuberculosis; TDM = Therapeutic … reverse transcriptase inhibitors, including tenofovir disoproxil fumarate (TDF), tenofovir alafenamide …
Table 4. Significant Pharmacokinetic Interactions Between Drugs Used to Treat or Prevent Opportunistic Infections
… Sofosbuvir Bedaquiline Doxycycline Linezolid Rifabutin Tenofovir Chloroquine Fluconazole Mefloquine Rifampin … Rifampin. Rifapentine a See Rifapentine. See Rifapentine. Tenofovir Alafenamide Glecaprevir/Pibrentasvir See … See Sofosbuvir/Velpatasvir. See Sofosbuvir/Velpatasvir. Tenofovir Disoproxil Fumarate Rifabutin a See Rifabutin. See …
Table 5. Serious and/or Common Adverse Reactions Associated with Systemically Administered Drugs Used to Treat or Prevent Opportunistic Infections
… Infusion- or injection-related reactions Thrombocytopenia Tenofovir Disoproxil Fumarate Renal insufficiency and … Decrease in bone mineral density Nausea and vomiting Tenofovir Alafenamide Lower incidence of renal or bone toxicities than with tenofovir disoproxil fumarate Trimethoprim-Sulfamethoxazole …
Table 6. Dosing Recommendations for Drugs Used to Treat or Prevent Opportunistic Infections that Require Dosage Adjustment in Adults With Renal Insufficiency
… Levofloxacin Posaconazole Pyrazinamide Quinine Rifabutin Tenofovir Trimethoprim Valacyclovir Voriconazole         … necessary. No dose adjustment necessary. Emtricitabine/ Tenofovir Alafenamide (FTC/TAF) (FDC Trade Name: Descovy) … on dialysis days, administer dose after HD. Emtricitabine/ Tenofovir Disoproxil Fumarate (FTC/TDF) (FDC Trade Name: …
Appendix A: List of Abbreviations
… SMX sulfamethoxazole TCA trichloroacetic acid TDF tenofovir disoproxil fumarate TMP trimethoprim TMP-SMX …
Table 5. Significant Drug Interactions for Drugs Used to Treat or Prevent Opportunistic Infections
… valacyclovir, valganciclovir, ganciclovir, cidofovir ARVs: tenofovir Immunosuppressive agents : mycophenolate Monitor … or ototoxic drugs Antimycobacterials : capreomycin ARVs: tenofovir Antivirals : cidofovir Caution advised. Avoid … : aminoglycosides Antivirals : foscarnet ARVs : tenofovir Nephrotoxic drugs Monitor for toxicities of these …