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What's New in the Guidelines
… Therapy During Pregnancy Bictegravir (BIC) plus tenofovir alafenamide (TAF) plus FTC (available as the … now include BIC plus TAF plus FTC  or  DTG plus (TAF or tenofovir disoproxil fumarate [TDF]) plus (FTC or 3TC). For …
Pre-exposure Prophylaxis (PrEP) to Prevent HIV During Periconception, Antepartum, and Postpartum Periods
… HIV prevention option for the individual patient (AIII). Tenofovir disoproxil fumarate plus emtricitabine is … are pregnant, postpartum, or breastfeeding. 3 Combination tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) as … regarding the risk of possible hepatitis flares when tenofovir-based PrEP is stopped. 36 See Hepatitis B …
Laboratory Testing for Initial Assessment and Monitoring of People With HIV
… infection; PR = protease; RT = reverse transcriptase; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate References Horberg M, Thompson …
Laboratory Testing: Plasma HIV-1 RNA (Viral Load) and CD4 Count Monitoring
… therapy with co-formulated bictegravir, emtricitabine and tenofovir alafenamide versus dolutegravir-based regimens. …
Laboratory Testing: Drug-Resistance Testing
… and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in … . Pozniak AL, Gallant JE, DeJesus E, et al. Tenofovir disoproxil fumarate, emtricitabine, and efavirenz …
Overview
… Transfer Inhibitors (INSTIs) Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Dosing … RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate Sources: Panel on …
What to Start: Initial Combination Antiretroviral Regimens
… second-generation INSTI plus two NRTIs—bictegravir (BIC)/tenofovir alafenamide (TAF)/‌emtricitabine (FTC) (AI) or dolutegravir (DTG) plus TAF/FTC or tenofovir disoproxil fumarate (TDF)/ FTC or TDF/lamivudine … transfer inhibitor; PrEP = pre-exposure prophylaxis; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; …
What to Start: Initial Antiretroviral Therapy Based on Specific Clinical Scenarios
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; TFV = tenofovir; UGT = uridine diphosphate glucuronosyltransferase …
What to Start: Initial Combination Regimens for the Antiretroviral-Naive Patient
… Most People with HIV (in alphabetical order): Bictegravir/tenofovir alafenamide/emtricitabine (AI) … (AI) Dolutegravir plus (emtricitabine or lamivudine) plus (tenofovir alafenamide or tenofovir disoproxil fumarate) a (AI) …
Recommendations for Use of Antiretroviral Drugs During Pregnancy: Overview
… with using Preferred and Alternative ARV drugs other than tenofovir disoproxil fumarate, emtricitabine, lamivudine, … especially among women and people also receiving tenofovir alafenamide (see Dolutegravir and Tenofovir Alafenamide ). 16,17 However, it is difficult to …
What to Start: Nucleoside Reverse Transcriptase Inhibitor Options
… reverse transcriptase inhibitor; RPV = rilpivirine; TAF = tenofovir alafenamide; TC = total cholesterol; TDF = tenofovir disoproxil fumarate Summary The U.S. Food and Drug … (ZDV), stavudine (d4T), didanosine (ddI), abacavir (ABC), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide …
What to Start: Integrase Strand Transfer Inhibitor Regimens
… RAL = raltegravir; STR = single-tablet regimen; TAF = tenofovir alafenamide; UGT = uridine diphosphate … INSTIs BIC and DTG have high barriers to resistance, BIC/tenofovir alafenamide (TAF)/‌emtricitabine (FTC) and DTG plus TAF/FTC or tenofovir disoproxil fumarate (TDF)/FTC are recommended for …
What to Start: Non-Nucleoside Reverse Transcriptase Inhibitor Regimens
… rate; RPV = rilpivirine; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate Summary Four non-nucleoside … the DRIVE-AHEAD trial, 734 participants received either DOR/tenofovir disoproxil fumarate (TDF)/lamivudine (3TC) or …
Initial Use of Antiretroviral Therapy During Pregnancy
… (INSTIs) dolutegravir (DTG) or bictegravir (BIC) plus a tenofovir-containing dual–‍nucleoside reverse transcriptase … Infection ) (AIII). Preferred regimens include: DTG plus (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) plus (emtricitabine [FTC] or …
What to Start: Protease Inhibitor–Based Regimens
… inhibitor; PK = pharmacokinetic; RTV = ritonavir; TAF = tenofovir alafenamide Summary The U.S. Food and Drug … each administered in combination with two NRTIs—either tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) or … Adults and Adolescents (the Panel) classifies DRV/r with (tenofovir alafenamide [TAF] or TDF) plus (FTC or 3TC) as a …
Previous Experience With Antiretroviral Medications but Not Currently on Antiretroviral Therapy During Current Pregnancy
… the use of the PI darunavir boosted with ritonavir with (tenofovir alafenamide or tenofovir disoproxil fumarate)plus (emtricitabine or …
What to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal
… Antiretroviral Regimens for Initial Therapy When Abacavir, Tenofovir Alafenamide, and Tenofovir Disoproxil Fumarate Cannot Be Used or Are Not … situations where it is desirable to avoid abacavir (ABC), tenofovir alafenamide (TAF), and tenofovir disoproxil … to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal …
Lack of Viral Suppression While on Antiretroviral Therapy in Pregnancy
… in South Africa (2021–2023), describing treatment with tenofovir/lamivudine/DTG initiated before 18 weeks of … in pregnancy drop postpartum in South African women on tenofovir-lamivudine-dolutegravir: a prospective cohort …
What to Start: Advantages and Disadvantages of Antiretroviral Components of Initial Antiretroviral Therapy
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; UGT = uridine diphosphate …
Table 6. What to Start: Initial Antiretroviral Regimens During Pregnancy
… = raltegravir; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine; v/v = …