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What's New in the Guidelines
… B and HIV when prescribing ARV regimens that do not include tenofovir. Added the two-drug ARV regimen doravirine … D virus infection. Clarified that, in certain situations, tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF) alone (without 3TC or …
Candida Infections
… but itraconazole may increase exposures and AEs from tenofovir disoproxil fumarate and tenofovir alafenamide. Most integrase strand transferase …
Principles of Antiretroviral Therapy
… latter typically being treated with a regimen that includes tenofovir with or without emtricitabine or lamivudine (or uses entecavir with an active non-tenofovir-containing ARV regimen) (see Hepatitis B Virus/HIV …
Laboratory Testing: Plasma HIV-1 RNA (Viral Load) and CD4 Count Monitoring
… therapy with co-formulated bictegravir, emtricitabine and tenofovir alafenamide versus dolutegravir-based regimens. …
Laboratory Testing: Drug-Resistance Testing
… and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in … . Pozniak AL, Gallant JE, DeJesus E, et al. Tenofovir disoproxil fumarate, emtricitabine, and efavirenz …
Baseline Evaluation
… a regimen with activity against hepatitis B virus (i.e., tenofovir alafenamide or tenofovir disoproxil fumarate with emtricitabine or …
COVID-19
… of HIV (e.g., lopinavir/‌ritonavir, boosted darunavir, or tenofovir disoproxil fumarate/emtricitabine) have efficacy …
Laboratory Testing for Initial Assessment and Monitoring of People With HIV
… infection; PR = protease; RT = reverse transcriptase; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate References Horberg M, Thompson …
Treatment Goals
… Lazzarin A, Mills A, et al. Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and … al. Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in …
What to Start: Initial Antiretroviral Therapy Based on Specific Clinical Scenarios
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; TFV = tenofovir; UGT = uridine diphosphate glucuronosyltransferase …
What to Start: Nucleoside Reverse Transcriptase Inhibitor Options
… for HBV without adding a potent anti-HBV therapy, such as tenofovir or entecavir. Consider alternative ARV medications … reverse transcriptase inhibitor; RPV = rilpivirine; TAF = tenofovir alafenamide; TC = total cholesterol; TDF = tenofovir disoproxil fumarate Summary Ten nucleos(t)ide …
What to Start: Integrase Strand Transfer Inhibitor Regimens
… RAL = raltegravir; STR = single-tablet regimen; TAF = tenofovir alafenamide; UGT = uridine diphosphate … INSTIs BIC and DTG have high barriers to resistance, BIC/tenofovir alafenamide (TAF)/‌emtricitabine (FTC), DTG plus (TAF or tenofovir disoproxil fumarate [TDF]) plus (FTC or lamivudine …
What to Start: Non-Nucleoside Reverse Transcriptase Inhibitor Regimens
… syndrome; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; TEN = toxic epidermal … trial, 734 treatment-naive participants received either DOR/tenofovir disoproxil fumarate (TDF)/lamivudine (3TC) or …
What to Start: Protease Inhibitor–Based Regimens
… applicable; PK = pharmacokinetic; RTV = ritonavir; TAF = tenofovir alafenamide Summary Ten protease inhibitors (PIs) … trial that compared the single-tablet regimen (STR) DRV/c/tenofovir alafenamide (TAF)/emtricitabine (FTC) with DRV/c plus tenofovir disoproxil fumarate (TDF)/FTC. At 48 weeks, …
What to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal
… Antiretroviral Regimens for Initial Therapy When Abacavir, Tenofovir Alafenamide, and Tenofovir Disoproxil Fumarate Cannot Be Used or Are Not … situations where it is desirable to avoid abacavir (ABC), tenofovir alafenamide (TAF), and tenofovir disoproxil … to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal …
What to Start: Advantages and Disadvantages of Antiretroviral Components of Initial Antiretroviral Therapy
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; UGT = uridine diphosphate …
Virologic Failure
… barrier plus two partially active NRTIs—particularly tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF) with lamivudine (3TC) or … an HBV-active drug with a high barrier to resistance (e.g., tenofovir alafenamide [TAF], tenofovir disoproxil fumarate …
What to Start: Initial Combination Antiretroviral Regimens
… transfer inhibitor; PrEP = pre-exposure prophylaxis; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; TFV = tenofovir Table 6b. Initial Antiretroviral Regimens for …
Hepatitis B Virus Infection
… HBV is recommended; the preferred regimen should include tenofovir (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) and either lamivudine (3TC) or …
Suboptimal CD4 Cell Recovery Despite Viral Suppression
… al. Switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from dolutegravir plus abacavir and …