Cytochrome P450 (CYP450)
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A group of enzymes involved in the breakdown of drugs in the liver. Many drugs can inhibit or enhance the activity of these enzymes, causing drug levels in the blood to increase or decrease. Cytochrome P450 (CYP450) enzymes metabolize all protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) and can cause drug interactions that may result in adverse effects.