HIV/AIDS Glossary

CXCR4 antagonists are a class of drugs that block the CXCR4 coreceptor on the surface of certain immune cells, such as CD4 T lymphocytes (CD4 cells). This prevents HIV from entering the cell. CXCR4 antagonists are part of a larger class of HIV drugs called entry inhibitors. Currently, CXCR4 antagonists are still under investigation and have not been approved by the Food and Drug Administration (FDA) for patient use.