Drug information

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Brand Name:
Shingrix
Other Names:
RZV, recombinant Varicella Zoster Virus (VZV) glycoprotein E, recombinant shingles vaccine, recombinant zoster vaccine
Drug Class:
Vaccines
What is Shingrix?What is Shingrix?

What is Shingrix?

Shingrix is a vaccine approved by the U.S. Food and Drug Administration (FDA) to prevent herpes zoster (shingles) in adults 50 years of age and older and in adults 18 years of age and older who are or will be at increased risk of getting shingles due to immunodeficiency or immunosuppression caused by disease or treatment.

Herpes zoster occurs when latent (inactive) varicella zoster virus (VZV) infection becomes reactivated in the body. VZV infection can be an opportunistic infection (OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? fact sheet.

The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV include recommendations on the use of Shingrix in people with HIV.

What should I tell my health care provider before receiving Shingrix?What should I tell my health care provider before receiving Shingrix?

What should I tell my health care provider before receiving Shingrix?

Before receiving Shingrix, tell your health care provider:

  • If you are allergic to any ingredients in Shingrix or any medicines. Tell your health care provider if you have ever had any reactions to a previous dose of the Shingrix vaccine.
  • About any medical conditions you have or have had.
  • About any health conditions that may prevent you from receiving medicine by injection.
  • If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of receiving Shingrix during pregnancy. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV may include other recommendations on the use of Shingrix during pregnancy. Please refer to these guidelines for additional information.
  • If you are breastfeeding or plan to breastfeed. For women with HIV in the United States, the Guideline does not recommend breastfeeding. Before your baby is born, or if you are already breastfeeding, talk to your health care provider to discuss alternative options for feeding your baby.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Shingrix may affect the way other medicines or products work, and other medicines or products may affect how Shingrix works. Ask your health care provider if there are interactions between Shingrix and the medicines you take.

Ask your health care provider about possible side effects from getting a Shingrix vaccine. Your health care provider will tell you what to do if you have side effects.

How is Shingrix given?How is Shingrix given?

How is Shingrix given?

A health care provider gives the Shingrix vaccine. The vaccine is given as an intramuscular injection. Vaccination with Shingrix is usually given as a series of two vaccine shots, with an interval between each dose. Read any printed information that your health care provider gives you about the Shingrix vaccine.

Where can I find more information about Shingrix vaccines?Where can I find more information about Shingrix vaccines?

Where can I find more information about Shingrix vaccines?

Last Reviewed: September 14, 2021