What are the most important things to know about tipranavir?
Tipranavir can cause serious, life-threatening side effects. These includeproblems, severe rash, and bleeding in the brain.
Some people taking tipranavir have had liver problems. A few people have died from these liver problems. People with a history of(HBV) or (HCV) or who have elevated results on liver function tests may have an increased risk of developing new or worsening liver problems while taking tipranavir. These people may need liver function tests more often.
Stop taking tipranavir (and ritonavir, an HIV medicine that is always used with tipranavir) and contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- General ill feeling
- Loss of appetite
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Pain, aching, or tenderness on your right side below your ribs
Stop taking tipranavir and contact your health care provider right away if you develop a rash and one or more of the following symptoms:
- Joint pain or stiffness
- Throat tightness
- Muscle aches
- Redness, blisters, or peeling of your skin
Report any unusual or unexplained bleeding to your health care provider.
While taking tipranavir, it is important to keep all of your appointments with your health care provider.
What is tipranavir?
Tipranavir is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children 2 years of age and older who meet specific requirements, as determined by a health care provider.
HIV medicines can't cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking tipranavir?
Before taking tipranavir, tell your health care provider:
- If you are allergic to tipranavir or any other medicines, including sulfa medicines.
- If you have or another medical condition that increases your risk of bleeding.
- If you are taking medicines that increase your risk of bleeding.
- If you have liver problems, including B infection (HBV) and hepatitis C virus infection (HCV).
- If you have high levels or high levels of .
- If you have .
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking tipranavir during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking tipranavir.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Tipranavir may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking tipranavir. For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. John's wort) you are taking or plan to take. Tipranavir may affect the way other medicines or products work, and other medicines or products may affect how tipranavir works. Taking tipranavir together with certain medicines or products may cause serious side effects.
How should I take tipranavir?
Tipranavir (brand name: Aptivus) comes in the following forms and strengths:
- 250-mg capsules
- 100-mg/mL oral solution
Take tipranavir according to your health care provider’s instructions.
Tipranavir capsules should be swallowed whole. Do not chew the capsules.
Tipranavir is always used with the HIV medicine ritonavir (brand name: Norvir). Take tipranavir and ritonavir at the same time. If you are taking tipranavir with ritonavir capsules or oral solution, the medicines can be taken with or without meals. If you are taking tipranavir with ritonavir tablets, the medicines must be taken with meals.
The oral solution of tipranavir contains vitamin E. If you take tipranavir oral solution, you can take a standard multivitamin, but do not take any other vitamin E supplements. Taking too much vitamin E during treatment with tipranavir may increase your risk of developing bleeding problems.
If you take too much tipranavir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take tipranavir, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof tipranavir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can tipranavir cause?
Tipranavir may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the ClinicalInfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of tipranavir can be serious or life-threatening. Serious side effects of tipranavir include liver problems, severe rash, and bleeding in the brain. (See section above: What are the most important things to know about tipranavir?)
Other possible side effects of tipranavir include:
- Diabetes and high blood sugar ( ).
- Changes in body fat ( ).
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Increases in the levels of certain fats (cholesterol and triglycerides) in the blood ( ).
- Increased bleeding in people with hemophilia.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of tipranavir. To learn more about possible side effects of tipranavir, read the drug label or or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should tipranavir be stored?
- Store unopened containers of tipranavir capsules in a refrigerator at 36°F to 46°F (2°C to 8°C). Store opened containers of tipranavir capsules at room temperature, 68°F to 77°F (20°C to 25°C). Once the container has been opened, the capsules must be used within 60 days.
- Store tipranavir oral solution at room temperature, 68°F to 77°F (20°C to 25°C). Do not refrigerate or freeze the oral solution. Once the container has been opened, the oral solution must be used within 60 days.
- Do not use tipranavir if the original seal over the container opening is broken or missing.
- Throw away tipranavir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep tipranavir and all medicines out of reach of children.
Where can I find more information about tipranavir?
More information about tipranavir is available:
Main number: 800-243-0127
Patient assistance: 800-556-8317
The above Patient Version drug summary is based on the following FDA label(s): Capsule (liquid filled), solution.
Last Reviewed: September 23, 2019