What is primaquine phosphate?
Primaquine phosphate is an antimalarial prescription medicine approved by the U.S.(FDA) for preventing of caused by the Plasmodium vivax (P. vivax).
Malaria can be an What is an Opportunistic Infection? fact sheet.(OI) of HIV. An OI is an that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the
How is primaquine phosphate used in people with HIV?
The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV include recommendations on the use of primaquine phosphate to prevent relapses of malaria caused by the parasites P. vivax or P. ovale in people with HIV.
The recommended uses may not always be consistent with FDA-approved uses of primaquine phosphate. See the Guidelines for complete information on recommended uses of primaquine phosphate in adults and adolescents with HIV. Primaquine phosphate may have other recommended uses not listed above.
What should I tell my health care provider before taking primaquine phosphate?
Before taking primaquine phosphate, tell your health care provider:
- If you are allergic to primaquine phosphate or any other medicines.
- About any medical conditions you have or have had.
- About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take tablets.
- If you are pregnant or plan to become pregnant. Primaquine phosphate should not be used during pregnancy. Talk to your health care provider about possible risks of taking primaquine phosphate during pregnancy. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV may include other recommendations on the use of primaquine phosphate during pregnancy. Please refer to these guidelines for additional information.
- If you are breastfeeding or plan to breastfeed. For women with HIV in the United States, the Guideline does not recommend breastfeeding. Before your baby is born, or if you are already breastfeeding, talk to your health care provider to discuss alternative options for feeding your baby.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Primaquine phosphate may affect the way other medicines or products work, and other medicines or products may affect how primaquine phosphate works. Ask your health care provider if there are interactions between primaquine phosphate and the other medicines you take.
Ask your health care provider about possible side effects from primaquine phosphate. Your health care provider will tell you what to do if you have side effects.
How should I take primaquine phosphate?
Take primaquine phosphate according to your health care provider’s instructions. Your health care provider will tell you how much primaquine phosphate to take and when to take it. Before you start primaquine phosphate and each time you get a refill, read any printed information that comes with your medicine.
How should primaquine phosphate be stored?
- Store primaquine phosphate tablets between 59°F and 86°F (15°C to 30°C).
- Keep primaquine phosphate tablets in the container that they came in and keep the container tightly closed. Protect the tablets from light.
- Do not use primaquine phosphate if the original seal over the container opening is broken or missing.
- Throw away primaquine phosphate that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep primaquine phosphate and all medicines out of reach of children.
Where can I find more information about primaquine phosphate?
- Recommendations on the HIV-related uses of primaquine phosphate, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, prepared by the , the , and the HIV Medicine Association of the Infectious Diseases Society of America.
- This Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
- Primaquine phosphate-related research studies, from .
Last Reviewed: August 5, 2020