What are the most important things to know about nevirapine?
Nevirapine can cause serious, life-threatening side effects. These include severeproblems, skin rash, and skin reactions. Liver and skin problems can happen at any time during treatment with nevirapine, but your risk is greatest during the first 18 weeks of treatment.
Stop taking nevirapine and contact your health care provider right away if you have any of the following symptoms of liver problems with or without skin rash:
- Dark-colored urine
- Yellowing of your skin or the whites of your eyes ( )
- Light-colored bowel movements
- Feeling unwell or like you have the flu
- Pain or tenderness on your right side below your ribs
- Loss of appetite
Stop taking nevirapine and contact your health care provider right away if you have a skin rash or reaction with any of the following symptoms:
- Mouth sores
- Redness or swelling of your eyes ( )
- Swelling of your face
- Feeling unwell or like you have the flu
- Muscle or joint aches
If your health care provider tells you to stop treatment with nevirapine because of serious liver or skin problems, you should never take nevirapine again.
While taking nevirapine, it is important to keep all of your appointments with your health care provider.
What is nevirapine?
Nevirapine is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children. Nevirapine comes in three different forms: immediate-release tablets and oral suspension (a liquid), and extended-release tablets. The immediate-release tablet and liquid forms of nevirapine are approved for use in adults and children 15 days and older. The extended-release tablets are approved for use in adults and in children 6 years of age and older who meet certain height and weight requirements.
Nevirapine is always used in combination with other HIV medicines.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking nevirapine?
Before taking nevirapine, tell your health care provider:
- If you are allergic to nevirapine or any other medicines.
- If you have or have ever had or other liver problems.
- If you are on or have ever received kidney dialysis.
- If you have trouble swallowing pills.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking nevirapine during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking nevirapine.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Nevirapine may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking nevirapine. For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products, especially St. John's wort, you are taking or plan to take. Nevirapine may affect the way other medicines or products work, and other medicines or products may affect how nevirapine works. Taking nevirapine together with certain medicines or products may cause serious side effects.
How should I take nevirapine?
Nevirapine comes in tablet form, either as immediate release tablets (brand name: Viramune) or extended release tablets (brand name: Viramune XR):
- 200-mg immediate-release tablets
- 100-mg extended-release tablets (only available in generic form)
- 400-mg extended-release tablets
Nevirapine also comes as an oral suspension (brand name: Viramune):
- 50-mg/5 mL oral suspension
Take nevirapine according to your health care provider’s instructions.
To reduce the risk of skin rash, only oneof immediate-release nevirapine is given each day for the first 14 days of treatment. If you do not have any reactions to nevirapine during the 14-day lead-in period, follow your health care provider’s instructions for taking two immediate-release nevirapine doses a day or switching to extended-release nevirapine. If you get a skin rash during the 14-day lead-in period, call your health care provider right away. Do not increase your nevirapine dose to two times a day or switch to taking nevirapine extended-release tablets if you have a rash.
Take nevirapine with or without food.
Never take more than one form of nevirapine at the same time.
The extended-release tablets should be swallowed whole and should not be chewed, crushed, or divided.
Nevirapine oral suspension is a liquid. Shake it gently before each use, and use an oral dosing syringe or dosing cup to measure the right dose. If the dose is less than one teaspoon (5 mL), use a syringe to measure the dose. (Ask your pharmacist for a syringe or dosing cup if you do not have one.) After drinking the medicine, fill the dosing cup with water and drink it to make sure you get all the medicine.
Always take nevirapine in combination with other HIV medicines.
If you take too much nevirapine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take nevirapine, see the FDA drug labels for nevirapine immediate-release tablets (brand name: Viramune), nevirapine extended-release tablets (brand name: Viramune XR), and nevirapine oral suspension (brand name: Viramune).
What should I do if I forget a dose?
If you miss a dose of nevirapine, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
If you stop taking nevirapine for more than 7 days, ask your health care provider how much to take before you start taking it again. You may need to begin nevirapine treatment again with a lead-in dose period.
What side effects can nevirapine cause?
Nevirapine may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the ClinicalInfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of nevirapine can be serious. Serious side effects of nevirapine include severe liver problems, skin rash, and skin reactions. The liver and skin problems can happen at any time during treatment with nevirapine, but your risk is greatest during the first 18 weeks of treatment. (See section above: What are the most important things to know about nevirapine?)
Other possible side effects of nevirapine include:
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Changes in body fat ( ).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of nevirapine. To learn more about possible side effects of nevirapine, read the drug label oror talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should nevirapine be stored?
- Store nevirapine at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep nevirapine in the container that it came in and keep the container tightly closed.
- Do not use nevirapine if the original seal over the container opening is broken or missing.
- Throw away nevirapine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep nevirapine and all medicines out of reach of children.
Where can I find more information about nevirapine?
More information about nevirapine is available:
- The drug labels for nevirapine immediate-release tablets (brand name: Viramune), nevirapine extended-release tablets (brand name: Viramune XR), and nevirapine oral suspension (brand name: Viramune)
- Nevirapine-related research studies, from the ClinicalInfo database of study summaries
- A list of FDA-approved HIV medicines, from ClinicalInfo
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Last Reviewed: March 2, 2020