What are the most important things to know about Kaletra?
Kaletra can cause serious, life-threatening side effects. These includeproblems, inflammation of the ( ), heart rhythm problems, severe allergic reactions, and life-threatening drug interactions.
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- Loss of appetite
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Itchy skin
- Pain in the stomach area (abdominal pain)
- Pain in the stomach area (abdominal pain)
- Sensation of abnormal heartbeats
Kaletra oral solution contains alcohol and propylene glycol. The added substances may cause side effects in babies taking Kaletra oral solution. Contact your health care provider right away if your baby appears too sleepy or his or her breathing changes.
Taking Kaletra with certain medicines may result in serious, life-threatening side effects.
While taking Kaletra, it is important to keep all of your appointments with your health care provider.
What is Kaletra?
Kaletra is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children 14 days of age and older. Kaletra is always used in combination with other HIV medicines.
Kaletra contains two different medicines: lopinavir and ritonavir.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking Kaletra?
Before taking Kaletra, tell your health care provider:
- If you have ever had a serious skin rash or an allergic reaction to either of the HIV medicines in Kaletra (lopinavir or ritonavir) or any other medicines.
- If you have or have ever had pancreas problems.
- If you have any liver problems, including (HBV) or (HCV).
- If you have any heart problems, including a condition called congenital long QT .
- If you have low potassium in your blood.
- If you have .
- If you have high in your blood.
- If you have .
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Kaletra oral solution contains alcohol and propylene glycol. Do not take Kaletra oral solution during pregnancy because there is no safe level of alcohol exposure during pregnancy. Talk to your health care provider about the risks and benefits of taking Kaletra during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking Kaletra.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Kaletra may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking Kaletra. For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. John's wort) you are taking or plan to take. Kaletra may affect the way other medicines or products work, and other medicines or products may affect how Kaletra works. Taking Kaletra together with certain medicines or products may cause serious, life-threatening side effects.
How should I take Kaletra?
Kaletra comes in tablet form in the following strengths:
Kaletra also comes as an oral solution that contains 80 mg/mL lopinavir and 20 mg/mL ritonavir.
Take Kaletra according to your health care provider’s instructions.
If you are giving Kaletra to your child, follow your health care provider’s instructions. Kaletra dosing for children is based on weight and height, so tell your health care provider if your child’s weight changes.
Kaletra tablets can be taken with or without food. Swallow the tablets whole. Do not chew, break, or crush the tablets.
Take Kaletra oral solution with food. Pregnant women should not take Kaletra oral solution, because it contains alcohol.
- If you take Kaletra tablets: You can take didanosine at the same time as Kaletra tablets, without food.
- If you take Kaletra oral solution: Take didanosine either 1 hour before or 2 hours after taking Kaletra oral solution.
If you take too much Kaletra, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Kaletra, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof Kaletra, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can Kaletra cause?
Kaletra may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the ClinicalInfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Kaletra can be serious. Serious side effects of Kaletra include liver problems, inflammation of the pancreas (pancreatitis), heart rhythm problems, severe allergic reactions, and life-threatening drug interactions. (See section above: What are the most important things to know about Kaletra?)
Other possible side effects of Kaletra include:
- Diabetes and high blood sugar ( ).
- Increases in the levels of certain fat (cholesterol and ) levels in your blood.
- Increased bleeding in people with hemophilia.
- Changes in body fat ( ).
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Kaletra. To learn more about possible side effects of Kaletra, read the drug label or or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should Kaletra be stored?
- Store Kaletra tablets at room temperature, 68°F to 77°F (20°C to 25°C). Keep Kaletra tablets in the container that they came in and keep the container tightly closed.
- Store Kaletra oral solution in a refrigerator at 36°F to 46°F (2°C to 8°C). The refrigerated oral solution can be used until the expiration date printed on the label. Kaletra oral solution that is stored at room temperature (less than 77°F or 25°C) should be used within 2 months. Keep the oral solution away from high heat.
- Do not use Kaletra if the original seal over the container opening is broken or missing.
- Throw away Kaletra that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Kaletra and all medicines out of reach of children.
Where can I find more information about Kaletra?
More information about Kaletra is available:
Main number: 800-633-9110
The above Patient Version drug summary is based on the following FDA label(s): Solution, tablet (film coated).
Last Reviewed: July 31, 2019