What are the most important things to know about Cimduo?
Cimduo can cause serious, life-threatening side effects. These include a buildup ofin the blood ( ), problems, and new or worsening kidney problems, including kidney failure.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
- Weakness or tiredness
- Unusual muscle pain
- Shortness of breath or fast breathing
- Stomach pain with nausea and vomiting
- Cold or blue hands and feet
- Dizziness or lightheadedness
- Fast or abnormal heartbeat
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Loss of appetite for several days or longer
- Nausea or vomiting
- Pain, aching, or tenderness on the right side of your stomach/abdominal area
If you have both HIV and(HBV) and take Cimduo, your HBV may get worse (flare up) if you stop taking Cimduo. Do not stop taking Cimduo without first talking to your health care provider.
Worsening of liver disease (sometimes resulting in death) has occurred in people with both HIV and ribavirin. If you are taking Cimduo, as well as interferon alfa with or without ribavirin, tell your health care provider if you have any new symptoms.(HCV) who were taking HIV medicines and alfa with or without
Contact your health care provider right away if you have any of the following symptoms that could be signs of a worsening kidney problem (called), which may be related to tenofovir-containing drugs:
- Bone pain that does not go away or gets worse
- Pain in your arms, hands, legs or feet
- Broken bones
- Muscle pain or weakness
While taking Cimduo, it is important to keep all of your appointments with your health care provider.
What is Cimduo?
Cimduo is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV infection in adults and children weighing at least 77 lb (35 kg). Cimduo is always used in combination with other HIV medicines.
For more information on the use of Cimduo in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.
Because lamivudine and tenofovir disoproxil fumarate are also effective against HBV infection, Cimduo may be included as part of an Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV and the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children.(ART) regimen to treat both HIV and HBV infection in people with HIV/HBV . For information on the HBV-related use of lamivudine and tenofovir disoproxil fumarate, please refer to the HBV section of the
What should I tell my health care provider before taking Cimduo?
Before taking Cimduo, tell your health care provider:
- If you are allergic to any of the HIV medicines in Cimduo (lamivudine and tenofovir disoproxil fumarate) or any other medicines.
- If you have liver problems, including HBV infection or HCV infection.
- If you have kidney problems, including (ESRD) that requires dialysis.
- If you have bone problems, including a history of broken bones.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Cimduo during pregnancy. For more information on the use of Cimduo during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States.
- If you are breast/chestfeeding or plan to breast/chestfeed. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the HIVinfo
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Cimduo may affect the way other medicines or products work, and other medicines or products may affect how Cimduo works. Taking Cimduo together with certain medicines or products may cause serious side effects.
How should I take Cimduo?
Cimduo comes in tablet form. Each tablet contains:
Take Cimduo according to your health care provider’s instructions. Do not miss aof Cimduo, and do not change your dose or stop taking Cimduo without first talking with your health care provider.
Take Cimduo by mouth with or without food.
Always take Cimduo in combination with other HIV medicines.
If you have taken too much Cimduo, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Cimduo, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof Cimduo, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can Cimduo cause?
Cimduo may cause side effects. Some side effects of Cimduo can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.Other possible side effects of Cimduo include:
- Inflammation of the ( ) in some children. Contact your health care provider right away if your child develops signs and symptoms of pancreatitis, including severe pain in the upper stomach/abdominal area, with or without nausea and vomiting.
- Bone problems, including bone pain, or softening or thinning of the bones ( ), which may lead to fractures.
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Changes in body fat ( ).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Cimduo. To learn more about possible side effects of Cimduo, read the drug label or or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should Cimduo be stored?
- Store Cimduo at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep Cimduo in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
- Do not use Cimduo if the original seal over the container opening is broken or missing.
- Throw away Cimduo that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Cimduo and all medicines out of reach of children.
Where can I find more information about Cimduo?
- For more information on the use of Cimduo in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
- This Patient Version drug summary is based on the following FDA label(s): Tablet. The Patient Information section includes information for people taking Cimduo.
- The American Hospital Formulary Service (AHFS) Patient Medication Information for lamivudine and tenofovir available from MedlinePlus.
- Cimduo-related research studies, from ClinicalTrials.gov. (The ClinicalTrials.gov search can be modified so that you can get results that better match your interests. To learn more about the ClinicalTrials.gov search features, please see How to Search.)
- A list of FDA-approved HIV medicines, from HIVinfo.
Main number: 724-514-1800
Patient assistance: 888-417-5780
Last Reviewed: April 10, 2022