Drug information

Other Names:
Drug Class:
Antifungal (Azole)
What is itraconazole?What is itraconazole?

What is itraconazole?


Itraconazole is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain fungal infections, including histoplasmosis (also known as Histoplasma capsulatum infection), esophageal candidiasis, oropharyngeal candidiasis, and others.

Esophageal candidiasis (infection of the esophagus) and oropharyngeal candidiasis (infection of part of the throat) are types of mucocutaneous candidiasis (also called mucosal candidiasis). Mucocutaneous candidiasis and histoplasmosis are both opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? fact sheet.

How is itraconazole used in people with HIV?How is itraconazole used in people with HIV?

How is itraconazole used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV include recommendations on the uses of itraconazole to:

  • Treat:
    • Histoplasmosis
    • Esophageal candidiasis
    • Oropharyngeal candidiasis
    • Uncomplicated vulvovaginal candidiasis (a type of mucocutaneous candidiasis)
    • Coccidioidomycosis
    • Cryptococcosis
    • Microsporidiosis, specifically disseminated infection caused by certain types of microsporidia
    • Talaromycosis (also known as Talaromyces marneffei infection)
  • Prevent:
    • Histoplasmosis from occurring the first time (called primary prophylaxis) and from recurring (called secondary prophylaxis or maintenance therapy)
    • Primary and secondary prophylaxis of talaromycosis    
    • Secondary prophylaxis of coccidioidomycosis
    • Secondary prophylaxis of oropharyngeal candidiasis

The recommended uses may not always be consistent with FDA-approved uses of itraconazole. See the guidelines for complete information on recommended uses of itraconazole in adults and adolescents with HIV. Some recommended uses, such as uses in certain rare circumstances, may have been omitted above.

What should I tell my health care provider before taking itraconazole?What should I tell my health care provider before taking itraconazole?

What should I tell my health care provider before taking itraconazole?

Before taking itraconazole, tell your health care provider:

  • If you are allergic to itraconazole or any other medicines.
  • About any medical conditions you have or have had, for example, heart or liver problems.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
  • If you are pregnant or plan to become pregnant. Women who are able to become pregnant must use effective forms of birth control during treatment with itraconazole and for two months after stopping. Talk to your health care provider about the risks and benefits of taking itraconazole during pregnancy.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Itraconazole may affect the way other medicines or products work, and other medicines or products may affect how itraconazole works. Ask your health care provider if there are interactions between itraconazole and the other medicines you take.

Ask your health care provider about possible side effects from itraconazole. Your health care provider will tell you what to do if you have side effects.

How should I take itraconazole?How should I take itraconazole?

How should I take itraconazole?

Take itraconazole according to your health care provider’s instructions. Your health care provider will tell you how much itraconazole to take and when to take it. Before you start itraconazole and each time you get a refill, read any printed information that comes with your medicine.

How should itraconazole be stored?How should itraconazole be stored?

How should itraconazole be stored?


  • Store itraconazole capsules at room temperature, 59°F to 77°F (15°C to 25°C). Protect the capsules from light and moisture.
  • Store itraconazole oral solution at or below 77°F (25°C). Do not freeze the oral solution.
  • Keep itraconazole in the container that it came in and keep the container tightly closed.
  • Do not use itraconazole if the original seal over the container opening is broken or missing.
  • Throw away itraconazole that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep itraconazole and all medicines out of reach of children.


Where can I find more information about itraconazole?Where can I find more information about itraconazole?

Where can I find more information about itraconazole?


More information about itraconazole is available:

The above Patient Version drug summary is based on the following FDA label(s): Capsule; Solution.


Last Reviewed: October 4, 2019