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Foscavir
Drug Class
Antiviral (Pyrophosphate Analog DNA Polymerase Inhibitor)
 

What is foscarnet sodium?What is foscarnet sodium?

What is foscarnet sodium?

Foscarnet sodium is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of cytomegalovirus (CMV) retinitis in individuals with AIDS. Foscarnet sodium is also FDA-approved for the treatment of a certain type of herpes simplex virus (HSV) infection, called acyclovir-resistant mucocutaneous HSV infection, in people with weakened immune systems.

CMV diseases—such as those affecting the eye (retinitis)—and HSV diseases can be opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? fact sheet.

How is foscarnet sodium used in people with HIV?How is foscarnet sodium used in people with HIV?

How is foscarnet sodium used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV and/or the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV include recommendations on the uses of foscarnet sodium in people with HIV to:

Treat: 

Prevent: 

  • CMV retinitis from recurring

The recommended uses may not always be consistent with FDA-approved uses of foscarnet sodium. See the Adult and Pediatric guidelines for complete information on recommended uses of foscarnet sodium in adults and children with HIV. Foscarnet sodium may have other recommended uses not listed above. 

What should I tell my health care provider before using foscarnet sodium?What should I tell my health care provider before using foscarnet sodium?

What should I tell my health care provider before using foscarnet sodium?

Before using foscarnet sodium, tell your health care provider:

  • If you are allergic to foscarnet sodium or any other medicines.
  • About any medical conditions you have or have had, including:
    • Kidney or liver problems
    • Mineral or electrolyte imbalance, such as low levels of calcium, magnesium, or potassium and low or high levels of phosphate
    • Seizures
    • Heart disease and heart rhythm problems
    • Dehydration
  • If you are on a low sodium (salt) diet.
  • About any health conditions that may prevent you from receiving medicine by injection or infusion.
  • If you are pregnant or plan to become pregnant. Foscarnet sodium should be used during pregnancy only if clearly needed. Talk to your health care provider about the risks and benefits of using foscarnet sodium during pregnancy. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV may include other recommendations on the use of foscarnet sodium during pregnancy. Please refer to these guidelines for additional information.
  • If you are breastfeeding or plan to breastfeed. For mothers with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. Mothers with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk. Although most medicines are safe to use while breastfeeding, some medicines should be avoided. Always let your health care provider know about all the medicines and supplements you are using before you start breastfeeding.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Foscarnet sodium may affect the way other medicines or products work, and other medicines or products may affect how foscarnet sodium works. Ask your health care provider if there are interactions between foscarnet sodium and the other medicines you take.

How should I use foscarnet sodium?How should I use foscarnet sodium?

How should I use foscarnet sodium?

Foscarnet sodium intravenous infusions are usually administered by a health care professional in a hospital or clinic. Some people may use foscarnet sodium at home. If you use foscarnet sodium at home, your health care provider will teach you how to use the medicine. It is important that you use foscarnet sodium exactly as your health care provider has instructed. If you do not understand how to use foscarnet sodium, ask your health care provider.

Foscarnet sodium intravitreal injection (injection into the eye) is administered by a health care professional in a hospital or clinic.

What side effects can foscarnet sodium cause?What side effects can foscarnet sodium cause?

What side effects can foscarnet sodium cause?

Foscarnet sodium may cause side effects that can be mild or serious. To learn about possible side effects of foscarnet sodium, see the FDA drug label or talk to your health care provider or pharmacist. Tell your health care professional if you have any side effect that bothers you or that does not go away. Your health care professional may be able to tell you about ways to prevent or reduce some side effects.

You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should foscarnet sodium be stored?How should foscarnet sodium be stored?

How should foscarnet sodium be stored?

  • Store foscarnet sodium injection at room temperature, 68°F to 77°F (20°C to 25°C), and protect it from excessive heat and from freezing.
  • Keep foscarnet sodium in the container that it came in and keep the container tightly closed.
  • Do not use foscarnet sodium if the original seal over the container opening is broken or missing.
  • Throw away foscarnet sodium that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine. For information on disposing of needles and other sharps, please refer to these guidelines or ask your health care provider or pharmacist.
  • Keep foscarnet sodium and all medicines out of reach of children.

Where can I find more information about foscarnet sodium?Where can I find more information about foscarnet sodium?

Where can I find more information about foscarnet sodium?

 

 

Last Reviewed: February 26, 2025