What are the most important things to know about Truvada?
Truvada can cause serious, life-threatening side effects. These include a buildup ofin the blood ( ), problems, and new or worsening kidney problems, including kidney failure.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
- Weakness or tiredness
- Unusual muscle pain
- Shortness of breath or fast breathing
- Stomach pain with nausea and vomiting
- Cold or blue hands and feet
- Dizziness or lightheadedness
- Fast or abnormal heartbeat
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Loss of appetite for several days or longer
- Nausea or vomiting
- Pain, aching, or tenderness on the right side of your stomach/abdominal area
If you have both HIV and(HBV) and take Truvada, your HBV infection may get much worse (flare up) if you stop taking Truvada. Do not stop taking Truvada without first talking with your health care provider.
Contact your health care provider right away if you have any of the following symptoms that could be signs of a worsening kidney problem (called), which may be related to tenofovir-containing drugs:
- Bone pain that does not go away or gets worse
- Pain in your arms, hands, legs, or feet
- Broken bones
- Muscle pain or weakness
Truvada can be used for(PrEP) to reduce the risk of getting HIV in people who are HIV negative. Do not use Truvada for PrEP unless a health care provider has confirmed that you do not have HIV.
While taking Truvada, it is important to keep all of your appointments with your health care provider.
What is Truvada?
Truvada is a prescription medicine approved by the U.S.(FDA) for the following uses:
- To treat HIV infection in adults and children who weigh at least 37 lb (17 kg). Truvada for HIV treatment is always used in combination with other HIV medicines.
- For HIV pre-exposure prophylaxis (PrEP) to reduce the risk of HIV infection in adults and adolescents who weigh at least 77 lb (35 kg), are HIV negative, and are at risk of getting HIV. Truvada for PrEP should always be used in combination with safer sex practices, such as using condoms.
For more information on the use of Truvada in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
For more information about HIV PrEP, including information on who should consider using PrEP, please read the HIVinfo fact sheet on PrEP.
HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. When used as treatment, HIV medicines also reduce the risk of HIV. Whether you are taking Truvada for HIV prevention or for HIV treatment (in combination with other HIV medicines), do not cut down on, skip, or stop taking your HIV medicine(s) unless your health care provider tells you to.
What should I tell my health care provider before taking Truvada?
Before taking Truvada, tell your health care provider:
- If you are allergic to either of the HIV medicines in Truvada (emtricitabine or tenofovir disoproxil fumarate) or any other medicines.
- If you have liver problems, including hepatitis B virus infection (HBV).
- If you have kidney problems or receive kidney dialysis treatment.
- If you have bone problems.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Truvada during pregnancy. For more information on the use of Truvada during pregnancy, please refer to the following sections of the Perinatal HIV Clinical Guidelines: Table 11. Antiretroviral Drug Use in Pregnant People with HIV and Pre-exposure Prophylaxis (PrEP) to Prevent HIV During Periconception, Antepartum, and Postpartum Periods.
- If you are breast/chestfeeding or plan to breast/chestfeed. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the HIVinfo
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Truvada may affect the way other medicines or products work, and other medicines or products may affect how Truvada works. Taking Truvada together with certain medicines or products may cause serious side effects.
Before taking Truvada for HIV PrEP, you must get tested to be sure you are HIV negative. Do not take Truvada for HIV PrEP unless you are confirmed to be HIV negative.
Before taking Truvada for PrEP, also tell your health care provider:
- If you had a flu-like illness anytime in the month before starting Truvada or if you have a flu-like illness at any time while taking Truvada. Flu-like symptoms may be a sign that you could have recently gotten HIV. The flu-like symptoms of a new HIV infection may include: tiredness, fever, nighttime sweating, rash, vomiting, diarrhea, joint or muscle aches, headache, sore throat, or enlarged in the neck or groin.
- If you think that you were exposed to HIV. Your health care provider may want to do more tests to be sure you are still HIV negative.
While taking Truvada for PrEP, you will get tested for HIV at least every 3 months.
How should I take Truvada?
Truvada comes in tablet form in the following strengths:
- 200 mg emtricitabine and 300 mg tenofovir disoproxil fumarate
- 167 mg emtricitabine and 250 mg tenofovir disoproxil fumarate
- 133 mg emtricitabine and 200 mg tenofovir disoproxil fumarate
- 100 mg emtricitabine and 150 mg tenofovir disoproxil fumarate
Take Truvada according to your health care provider’s instructions. Do not miss aof Truvada, and do not change your dose or stop taking Truvada without first talking with your health care provider.
Take Truvada with or without food at the same time each day.
Take Truvada tablets whole. Tell your healthcare provider if you or your child cannot swallow Truvada tablets.
If you take Truvada to treat HIV infection, always take it in combination with other HIV medicines.
If you take Truvada for PrEP, take it every day and not just when you think that you were exposed to HIV. Always use PrEP in combination with condoms and other safer sex practices.
If you have taken too much Truvada, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Truvada, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof Truvada, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can Truvada cause?
Truvada may cause side effects. Some side effects of Truvada can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.
Other possible side effects of Truvada include:
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Bone problems, including bone pain, or softening or thinning of the bones ( ), which may lead to fractures.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Truvada. To learn more about possible side effects of Truvada, read the drug label or or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should Truvada be stored?
- Store Truvada at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep Truvada in the container that it came in and keep the container tightly closed.
- Do not use Truvada if the original seal over the container opening is broken or missing.
- Throw away Truvada that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Truvada and all medicines out of reach of children.
Where can I find more information about Truvada?
- For more information on the use of Truvada in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
- This Patient Version drug summary is based on the following FDA label(s): Tablet (film coated). The Medication Guide includes information for people taking Truvada.
- The American Hospital Formulary Service (AHFS) Patient Medication Information for emtricitabine and tenofovir available from MedlinePlus.
- Truvada-related research studies, from . (The ClinicalTrials.gov search can be modified so that you can get results that better match your interests. To learn more about the ClinicalTrials.gov search features, please see How to Search.)
- A fact sheet about PrEP, from HIVinfo.
- A list of FDA-approved HIV medicines, from HIVinfo.
Gilead Sciences, Inc.
Main number: 800-445-3235
Patient assistance: 800-226-2056
Last Reviewed: January 31, 2022