Drug information

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Brand Name
Other Names
DOR/3TC/TDF, doravirine/lamivudine/TDF, doravirine/lamivudine/tenofovir DF
Drug Class
Combination Drugs
Non-Nucleoside Reverse Transcriptase Inhibitor (doravirine)
Nucleoside Reverse Transcriptase Inhibitor (lamivudine, tenofovir DF)
Drug Image(s): (Click to enlarge)
What are the most important things to know about Delstrigo?What are the most important things to know about Delstrigo?

What are the most important things to know about Delstrigo?


Delstrigo can cause serious, life-threatening side effects. These include new or worsening kidney problems, including kidney failure, and hepatitis B virus infection (HBV) flare-ups.

Contact your health care provider right away if you have any of the following symptoms that could be signs of a worsening kidney problem (called Fanconi Syndrome) which may be related to tenofovir-containing drugs:

  • Bone pain that does not go away or gets worse
  • Pain in your arms, legs, hands, or feet
  • Broken bones
  • Muscle pain or weakness

If you have both HIV and HBV and take Delstrigo, your HBV infection may get much worse (flare-up) if you stop taking Delstrigo. Do not stop taking Delstrigo without first talking with your health care provider.

While taking Delstrigo, it is important to keep all of your appointments with your health care provider.

What is Delstrigo?What is Delstrigo?

What is Delstrigo?

Delstrigo is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who meet certain requirements, as determined by a healthcare provider.

Delstrigo is a complete HIV treatment regimen and should not be used with other HIV medicines.

Delstrigo contains three different medicines: doravirine, lamivudine, and tenofovir disoproxil fumarate.

For more information on the use of Delstrigo in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.

HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.

What should I tell my health care provider before taking Delstrigo?What should I tell my health care provider before taking Delstrigo?

What should I tell my health care provider before taking Delstrigo?

Before taking Delstrigo, tell your health care provider:

  • If you are allergic to any of the HIV medicines in Delstrigo (doravirine, lamivudine, or tenofovir disoproxil fumarate) or any other medicines.
  • If you have hepatitis B virus infection (HBV).
  • If you have kidney problems.
  • If you have bone problems, including a history of broken bones.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Delstrigo during pregnancy. For more information on the use of Delstrigo during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States.
  • If you are breastfeeding or plan to breastfeed. For women with HIV in the United States, the Guideline does not recommend breastfeeding. Before your baby is born, or if you are already breastfeeding, talk to your health care provider to discuss alternative options for feeding your baby.
  • If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the HIVinfo HIV and Birth Control infographic.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. John's wort) you are taking or plan to take. Delstrigo may affect the way other medicines or products work, and other medicines or products may affect how Delstrigo works. Taking Delstrigo together with certain medicines or products may cause serious side effects.
How should I take Delstrigo?How should I take Delstrigo?

How should I take Delstrigo?

Delstrigo comes in tablet form. Each tablet contains:

Take Delstrigo according to your health care provider’s instructions.

Take Delstrigo by mouth with or without food. Delstrigo is usually taken without other HIV medicines.

If you also take the medicine rifabutin during treatment with Delstrigo, you may not have enough doravirine in your blood. (Doravirine is one of the medicines in Delstrigo.) Your health care provider will prescribe an additional dose of doravirine for you to take. Follow your health care provider’s instructions about when to take doravirine and how much to take. This is usually one tablet of doravirine about 12 hours after your last dose of Delstrigo.

If you have taken too much Delstrigo, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take Delstrigo, see the FDA drug label.

What should I do if I forget a dose?What should I do if I forget a dose?

What should I do if I forget a dose?

If you miss a dose of Delstrigo, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can Delstrigo cause?What side effects can Delstrigo cause?

What side effects can Delstrigo cause?

Delstrigo may cause side effects. Some side effects of Delstrigo can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of Delstrigo include:

  • Bone problems (bone pain, softening, or thinning [osteopenia]), which may lead to fractures.
  • Changes in your immune system (called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Delstrigo. To learn more about possible side effects of Delstrigo, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should Delstrigo be stored?How should Delstrigo be stored?

How should Delstrigo be stored?

  • Store Delstrigo at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep Delstrigo in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
  • Do not use Delstrigo if the original seal over the container opening is broken or missing.
  • Throw away Delstrigo that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep Delstrigo and all medicines out of reach of children.
Where can I find more information about Delstrigo?Where can I find more information about Delstrigo?

Where can I find more information about Delstrigo?

Manufacturer Information

Merck & Co., Inc.
Main number: 877-888-4231
Patient assistance: 800-727-5400


Last Reviewed: October 13, 2021