Drug information

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Brand Name
Juluca
Other Names
DTG/RPV, dolutegravir sodium / rilpivirine hydrochloride
Drug Class
Combination Drugs
Integrase Strand Transfer Inhibitor (dolutegravir)
Non-Nucleoside Reverse Transcriptase Inhibitor (rilpivirine)
Drug Image(s): (Click to enlarge)
 
What are the most important things to know about Juluca?What are the most important things to know about Juluca?

What are the most important things to know about Juluca?

Juluca can cause serious, life-threatening side effects. These include severe skin rash and allergic reactions, liver problems, depression or mood changes, and drug interactions.

Contact your health care provider right away if you develop a rash while taking Juluca. Stop taking Juluca and get medical help right away if you develop a rash with any of the following signs or symptoms:

  • General ill feeling
  • Extreme tiredness
  • Muscle or joint aches
  • Fever
  • Blistering or peeling skin
  • Blisters or sores in your mouth
  • Redness or swelling of the eyes (conjunctivitis)
  • Swelling of your face, lips, mouth, tongue, or throat
  • Trouble breathing or swallowing

Some people taking Juluca may develop liver problems. People with a history of hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV) may have an increased risk of developing new or worsening liver problems while taking Juluca. Liver function tests may be done before and during treatment with Juluca. 

Contact your health care provider right away if you develop any of the following symptoms that could be signs of liver problems:

  • Yellowing of your skin or the whites of your eyes (jaundice)
  • Dark-colored urine
  • Light-colored bowel movements
  • Loss of appetite for several days or longer
  • Nausea or vomiting
  • Pain, aching, or tenderness on the right side of your stomach area/abdominal area
  • Itching

Contact your health care provider right away or get medical help if you have any of the following symptoms that could be signs of depression or mood changes:

  • Feeling sad or hopeless
  • Feeling anxious or restless
  • Harming yourself or having thoughts about harming yourself (including suicidal thoughts)

Taking Juluca with certain other medicines may result in serious, life-threatening side effects. Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

While taking Juluca, it is important to keep all of your appointments with your health care provider.

What is Juluca?What is Juluca?

What is Juluca?

Juluca is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who meet specific requirements, as determined by a health care provider.

Juluca is a complete HIV treatment regimen and should not be used with other HIV medicines. 

Juluca contains two different medicines: dolutegravir and rilpivirine.

For more information on the use of Juluca in people with HIV, please refer to the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV.

HIV medicines cannot cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, do not cut down on, skip, or stop taking them unless your health care provider tells you to.

What should I tell my health care provider before taking Juluca?What should I tell my health care provider before taking Juluca?

What should I tell my health care provider before taking Juluca?

Before taking Juluca, tell your health care provider:

  • If you are allergic to any of the HIV medicines in Juluca (dolutegravir or rilpivirine) or any other medicines.
  • If you have or have ever had liver problems, including hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV).
  • If you have ever had a mental health problem.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Juluca during pregnancy. For more information on the use of Juluca during pregnancy, please refer to the Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States.
  • If you are breastfeeding or plan to breastfeed. For women with HIV in the United States, the Guideline does not recommend breastfeeding. Before your baby is born, or if you are already breastfeeding, talk to your health care provider to discuss alternative options for feeding your baby.
  • If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the HIVinfo HIV and Birth Control infographic.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. John’s wort) you are taking or plan to take. Juluca may affect the way other medicines or products work, and other medicines or products may affect how Juluca works. Taking Juluca together with certain medicines or products may cause serious, life-threatening side effects.
How should I take Juluca?How should I take Juluca?

How should I take Juluca?

Juluca comes in tablet form. Each tablet contains:

Take Juluca according to your health care provider’s instructions. Do not miss a dose of Juluca, and do not change your dose or stop taking Juluca without first talking with your health care provider.

Always take Juluca with a meal. (A protein drink is not a substitute for a meal.) If you are taking any other medicines or supplements, including antacids or laxatives, carefully follow instructions on how to take them with Juluca.

If you have taken too much Juluca, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room. 

For more information on how to take Juluca, see the FDA drug label.

What should I do if I forget a dose?What should I do if I forget a dose?

What should I do if I forget a dose?

If you miss a dose of Juluca, take the missed dose as soon as you remember it. (Take the missed dose with a meal.) But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can Juluca cause?What side effects can Juluca cause?

What side effects can Juluca cause?

Juluca may cause side effects. Some side effects of Juluca can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of Juluca include diarrhea and headache.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Juluca. To learn more about possible side effects of Juluca, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should Juluca be stored?How should Juluca be stored?

How should Juluca be stored?

  • Store Juluca at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep Juluca in the container that it came in. Keep the container tightly closed and away from moisture. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
  • Do not use Juluca if the original seal over the container opening is broken or missing.
  • Throw away Juluca that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep Juluca and all medicines out of reach of children.
Where can I find more information about Juluca?Where can I find more information about Juluca?

Where can I find more information about Juluca?

Manufacturer Information

ViiV Healthcare

Main number: 877-844-8872
Patient assistance (ViiV Connect): 844-588-3288

 

Last Reviewed: December 19, 2021