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Management of Children Receiving Antiretroviral Therapy


In the United States, the majority of children with HIV are receiving antiretroviral therapy (ART), making treatment-experienced children the norm. Providers may consider antiretroviral (ARV) regimen changes for the following reasons:

  • Treatment simplification: Modifying ARV regimens in children who are currently receiving effective ART in order to simplify the regimen.
  • Treatment optimization: Increasing the treatment potency or barrier to resistance of an effective but older or potentially fragile regimen or improving the adverse event profile.
  • Toxicity management: Recognizing and managing ARV drug toxicity or intolerance (see Management of Medication Toxicity or Intolerance).
  • Treatment failure: Recognizing and managing treatment failure (see Recognizing and Managing Antiretroviral Treatment Failure).

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