Appendix B: Drug Characteristics Tables
Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
Appendix B, Table 2. Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
The following table includes dose recommendations for FDA-approved, dual-NRTI FDC products. These FDC tablets are not complete regimens and must be administered in combination with other ARV drugs.
Please see the class-specific drug characteristics tables (Appendix B, Tables 3 to 6) for details about the individual drugs contained in these FDC products, including information on elimination and metabolic pathways, serum and intracellular half-lives, and adverse effects. The FDC tablets in this table are listed by trade name.
| Trade Name (Abbreviations) |
ARV Drugs Included in the FDC Tablet | Dosing Recommendationa |
|---|---|---|
| TAF or TDF plus an NRTI | ||
| Descovy (TAF/FTC) |
Tenofovir alafenamide 25 mg/emtricitabine 200 mg | One tablet once daily |
| Cimduo (TDF/3TC) |
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg | One tablet once daily |
| Temixys (TDF/3TC) |
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg | One tablet once daily |
| Truvada (TDF/FTC) |
Tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg | One tablet once daily |
| Other NRTI-Based, FDC Tablets | ||
| Epzicom (ABC/3TC) Note: Generic product is available. |
Abacavir 600 mg/lamivudine 300 mg | One tablet once daily |
| Combivir (ZDV/3TC) Note: Generic product is available. |
Zidovudine 300 mg/lamivudine 150 mg | One tablet twice daily |
| a For dose adjustments in patients with renal or hepatic insufficiency, see Appendix B, Table 10. All FDC tablets listed in this table can be taken without regard to food. Key: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; FDA = Food and Drug Administration; FDC = fixed-dose combination; FTC = emtricitabine; NRTI = nucleoside reverse transcriptase inhibitor; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine |
||
Appendix B: Drug Characteristics Tables
Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
Appendix B, Table 2. Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
The following table includes dose recommendations for FDA-approved, dual-NRTI FDC products. These FDC tablets are not complete regimens and must be administered in combination with other ARV drugs.
Please see the class-specific drug characteristics tables (Appendix B, Tables 3 to 6) for details about the individual drugs contained in these FDC products, including information on elimination and metabolic pathways, serum and intracellular half-lives, and adverse effects. The FDC tablets in this table are listed by trade name.
| Trade Name (Abbreviations) |
ARV Drugs Included in the FDC Tablet | Dosing Recommendationa |
|---|---|---|
| TAF or TDF plus an NRTI | ||
| Descovy (TAF/FTC) |
Tenofovir alafenamide 25 mg/emtricitabine 200 mg | One tablet once daily |
| Cimduo (TDF/3TC) |
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg | One tablet once daily |
| Temixys (TDF/3TC) |
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg | One tablet once daily |
| Truvada (TDF/FTC) |
Tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg | One tablet once daily |
| Other NRTI-Based, FDC Tablets | ||
| Epzicom (ABC/3TC) Note: Generic product is available. |
Abacavir 600 mg/lamivudine 300 mg | One tablet once daily |
| Combivir (ZDV/3TC) Note: Generic product is available. |
Zidovudine 300 mg/lamivudine 150 mg | One tablet twice daily |
| a For dose adjustments in patients with renal or hepatic insufficiency, see Appendix B, Table 10. All FDC tablets listed in this table can be taken without regard to food. Key: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; FDA = Food and Drug Administration; FDC = fixed-dose combination; FTC = emtricitabine; NRTI = nucleoside reverse transcriptase inhibitor; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine |
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