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What to Start: Integrase Strand Transfer Inhibitor Regimens
… RAL = raltegravir; STR = single-tablet regimen; TAF = tenofovir alafenamide; UGT = uridine diphosphate … INSTIs BIC and DTG have high barriers to resistance, BIC/tenofovir alafenamide (TAF)/‌emtricitabine (FTC) and DTG plus TAF/FTC or tenofovir disoproxil fumarate (TDF)/FTC are recommended for …
Initial Use of Antiretroviral Therapy During Pregnancy
… (INSTIs) dolutegravir (DTG) or bictegravir (BIC) plus a tenofovir-containing dual–‍nucleoside reverse transcriptase … Infection ) (AIII). Preferred regimens include: DTG plus (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) plus (emtricitabine [FTC] or …
What to Start: Non-Nucleoside Reverse Transcriptase Inhibitor Regimens
… rate; RPV = rilpivirine; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate Summary Four non-nucleoside … the DRIVE-AHEAD trial, 734 participants received either DOR/tenofovir disoproxil fumarate (TDF)/lamivudine (3TC) or …
What to Start: Protease Inhibitor–Based Regimens
… inhibitor; PK = pharmacokinetic; RTV = ritonavir; TAF = tenofovir alafenamide Summary The U.S. Food and Drug … each administered in combination with two NRTIs—either tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) or … Adults and Adolescents (the Panel) classifies DRV/r with (tenofovir alafenamide [TAF] or TDF) plus (FTC or 3TC) as a …
Previous Experience With Antiretroviral Medications but Not Currently on Antiretroviral Therapy During Current Pregnancy
… the use of the PI darunavir boosted with ritonavir with (tenofovir alafenamide or tenofovir disoproxil fumarate)plus (emtricitabine or …
What to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal
… Antiretroviral Regimens for Initial Therapy When Abacavir, Tenofovir Alafenamide, and Tenofovir Disoproxil Fumarate Cannot Be Used or Are Not … situations where it is desirable to avoid abacavir (ABC), tenofovir alafenamide (TAF), and tenofovir disoproxil … to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal …
What to Start: Advantages and Disadvantages of Antiretroviral Components of Initial Antiretroviral Therapy
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; UGT = uridine diphosphate …
Lack of Viral Suppression While on Antiretroviral Therapy in Pregnancy
… in South Africa (2021–2023), describing treatment with tenofovir/lamivudine/DTG initiated before 18 weeks of … in pregnancy drop postpartum in South African women on tenofovir-lamivudine-dolutegravir: a prospective cohort …
Table 6. What to Start: Initial Antiretroviral Regimens During Pregnancy
… = raltegravir; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine; v/v = …
Teratogenicity
… = rilpivirine; RTV = ritonavir; T‑20 = enfuvirtide; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine For …
Hepatitis B Virus/HIV Coinfection
… administration of a HBV vaccines series (AII). Because tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), lamivudine (3TC) and … coinfection during pregnancy, an ART regimen that includes tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide …
HIV-2 and Pregnancy
… those recommended for treatment of HIV-1 during pregnancy: tenofovir disoproxil fumarate or tenofovir alafenamide plus emtricitabine (FTC) or lamivudine …
Early (Acute and Recent) HIV Infection
… for initial ART b (AIII): Dolutegravir (DTG) with (tenofovir alafenamide fumarate [TAF] or tenofovir disoproxil fumarate [TDF]) c plus (emtricitabine … infection, a regimen that includes dolutegravir (DTG) with tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide …
Hepatitis B Virus Infection
… HBV is recommended; the preferred regimen should include tenofovir (tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) and either lamivudine (3TC) or …
Virologic Failure
… barrier plus two partially active NRTIs—particularly tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF) with lamivudine (3TC) or … an HBV-active drug with a high barrier to resistance (e.g., tenofovir alafenamide [TAF], tenofovir disoproxil fumarate …
Cytomegalovirus Disease
… other potentially nephrotoxic medications, including tenofovir disoproxil fumarate. Periodic ophthalmologic …
Special Considerations for Antiretroviral Therapy Use in Adolescents With HIV
… Many ARV drugs (e.g., abacavir, emtricitabine, lamivudine, tenofovir disoproxil fumarate [TDF], some protease …
Suboptimal CD4 Cell Recovery Despite Viral Suppression
… al. Switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from dolutegravir plus abacavir and …
Optimizing Antiretroviral Therapy in the Setting of Viral Suppression
… if an NRTI is to be included in the new regimen, two NRTIs (tenofovir alafenamide [TAF] or tenofovir disoproxil fumarate [TDF] plus emtricitabine [FTC] … coinfection (hepatitis B surface antigen [HBsAg] positive), tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide …
Hepatitis C Virus Infection
… the following: Velpatasvir can increase concentrations of tenofovir disoproxil fumarate and lead to tenofovir-related renal toxicity. It is unclear at this time whether this is also the case with tenofovir alafenamide. Nevertheless, care should be taken in …