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Cardiovascular Complications in People With HIV
… of a first MACE with ART regimens, including ABC versus tenofovir-containing regimens, 33 and an increased MACE … (HDL), and triglycerides have been observed with tenofovir alafenamide (TAF), efavirenz (EFV), all boosted … who received TAF when compared with those who received tenofovir disoproxil fumarate (TDF) in multiple randomized …
Weight Gain in People With Treated HIV
… reverse transcriptase inhibitor (NNRTI)–based and tenofovir disoproxil fumarate (TDF)–based regimens. 6-9 … and the nucleotide reverse transcriptase inhibitor (NRTI) tenofovir alafenamide (TAF), 11,13 especially when compared … . Lake JE, Trevillyan J. Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV. …
Special Populations: Adolescents and Young Adults With HIV
… regimens. Bictegravir (BIC) coformulated with tenofovir alafenamide (TAF) and emtricitabine (FTC) also has … risk of side effects, such as bone and renal toxicity with tenofovir-based drugs in rapidly growing adolescents. These … peak bone mass, TAF generally should be used instead of tenofovir disoproxil fumarate, because of a greater bone …
Special Populations: Early (Acute and Recent) HIV Infection
… ARV regimens is recommended b (AIII): Bictegravir (BIC)/tenofovir alafenamide (TAF)/emtricitabine (FTC) Dolutegravir (DTG) with (TAF or tenofovir disoproxil fumarate [TDF]) c plus (FTC or … of the INSTI genotype. c TAF and TDF are two forms of tenofovir that are approved in the United States. TAF has …
Special Populations: HIV-2 Infection
… controlled trial comparing raltegravir (RAL) plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) to … D, Gallien S, et al. First-line raltegravir/emtricitabine/tenofovir combination in human immunodeficiency virus type 2 … regimen of elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate for the initial treatment of …
Special Populations: HIV and the Older Person
… to the marked fracture risk. ART regimens that contain tenofovir disoproxil fumarate (TDF), 27 boosted protease … (INSTIs). 28-31 Abacavir (ABC), NRTI-sparing regimens, and tenofovir alafenamide (TAF) may be considered as … density after initiation of antiretroviral treatment with tenofovir disoproxil fumarate/emtricitabine plus …
Special Populations: Substance Use Disorders and HIV
… with HBV/HIV coinfection unless HBV-active drugs (i.e., tenofovir, entecavir) are included in the regimen. Because … in an urban safety-net HIV clinic reported increases in tenofovir-reactive urine tests and stimulant-negative urine …
Special Populations: Transplantation in People With HIV
… and efficacy of the new regimen before transplant (BIII). Tenofovir alafenamide (TAF) is preferred over tenofovir disoproxil fumarate (TDF) in transplant candidates … = raltegravir; RPV = rilpivirine; RTV = ritonavir; TDF = tenofovir disoproxil fumarate; TDM = therapeutic drug …
Hepatitis B Virus/HIV Coinfection
… be stopped in people with HBV/HIV (AII).  Before Initiating Tenofovir-Sparing Antiretroviral Regimens People with HIV … should have their HBV status verified before initiating a tenofovir-sparing ARV regimen. See  Optimizing … must be given if the selected ARV regimen does not contain tenofovir (AII).  TAF or TDF are preferred for HBV treatment …
Hepatitis C Virus/HIV Coinfection
… HBV = hepatitis B virus; HCV = hepatitis C virus; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate The treatment of hepatitis C … HBV (positive HBsAg) should receive ART that includes tenofovir alafenamide or tenofovir disoproxil fumarate, or …
Tuberculosis/HIV Coinfection
… or clinically suspected INSTI resistance) (AIII). Tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) (AIII), tenofovir alafenamide (TAF)/FTC (BIII), or abacavir … DTG dosing (AII). When prescribing either 1HP or 3HP, tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) …
Special Populations: Women With HIV
… by HIV and some ARV drugs. 19-22 ARV regimens that contain tenofovir disoproxil fumarate (TDF), boosted protease … a 12.3­kg weight gain was recorded among women receiving tenofovir alafenamide (TAF)/emtricitabine (FTC)/DTG compared … Two small studies showed no difference in plasma levels of tenofovir and RAL between pre- and postmenopausal women. …
Cost Considerations and Antiretroviral Therapy
… during the 2026 and 2027 cycles, Biktarvy (bictegravir/tenofovir alafenamide/emtricitabine) has been selected for … established clinical safety and efficacy, such as generic tenofovir disoproxil fumarate (TDF), which has been … of generic TDF-based regimens versus branded tenofovir alafenamide (TAF)–based regimens. 62 The study …
Drug-Drug Interactions
… = rilpivirine; RTV = ritonavir; SQ = subcutaneous; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; UGT = uridine diphosphate … pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients. AIDS Patient Care STDS . …
Appendix A. Drug Characteristics Tables
… Dosing Recommendation a INSTI Plus Two NRTIs Bictegravir/Tenofovir Alafenamide/Emtricitabine (BIC/TAF/FTC) Biktarvy … 300 mg One tablet PO once daily Elvitegravir/Cobicistat/Tenofovir Alafenamide/Emtricitabine (EVG/c/TAF/FTC) Genvoya … One tablet PO once daily with food Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine (EVG/c/TDF/FTC) …
Appendix C: Drug Name Abbreviations
… RTV or r ritonavir SQV saquinavir T-20 enfuvirtide TAF tenofovir alafenamide TDF tenofovir disoproxil fumarate TFV tenofovir TFV-DP tenofovir-diphosphate TMP-SMX …