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What's New in the Guidelines
… reverse transcriptase inhibitors, (i.e., tenofovir disoproxil fumarate or tenofovir alafenamide [TAF] with 3TC or FTC; ABC and 3TC). …
Preventing HIV Transmission During Infant Feeding
… infant. 92 NRTIs show more variability than PIs and NNRTIs. Tenofovir concentrations from tenofovir disoproxil fumarate (TDF) are very low in breast … Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk …
Laboratory Testing for Initial Assessment and Monitoring of People With HIV
… infection; PR = protease; RT = reverse transcriptase; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate References Horberg M, Thompson …
Laboratory Testing: Plasma HIV-1 RNA (Viral Load) and CD4 Count Monitoring
… therapy with co-formulated bictegravir, emtricitabine and tenofovir alafenamide versus dolutegravir-based regimens. …
Laboratory Testing: Drug-Resistance Testing
… and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in … . Pozniak AL, Gallant JE, DeJesus E, et al. Tenofovir disoproxil fumarate, emtricitabine, and efavirenz …
Clinical and Laboratory Monitoring of Pediatric HIV Infection
… HgbA1C = glycosylated hemoglobin; RPV = rilpivirine; TAF = tenofovir alafenamide; TB = tuberculosis; TDF = tenofovir disoproxil fumarate Table 7. Primary U.S. Food and …
What to Start: Initial Antiretroviral Therapy Based on Specific Clinical Scenarios
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; TFV = tenofovir; UGT = uridine diphosphate glucuronosyltransferase …
What to Start: Initial Combination Regimens for the Antiretroviral-Naive Patient
… Most People with HIV (in alphabetical order): Bictegravir/tenofovir alafenamide/emtricitabine (AI) … (AI) Dolutegravir plus (emtricitabine or lamivudine) plus (tenofovir alafenamide or tenofovir disoproxil fumarate) a (AI) …
What to Start: Initial Combination Antiretroviral Regimens
… second-generation INSTI plus two NRTIs—bictegravir (BIC)/tenofovir alafenamide (TAF)/‌emtricitabine (FTC) (AI) or dolutegravir (DTG) plus TAF/FTC or tenofovir disoproxil fumarate (TDF)/ FTC or TDF/lamivudine … transfer inhibitor; PrEP = pre-exposure prophylaxis; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; …
What to Start: Antiretroviral Treatment Regimens Recommended for Initial Therapy in Infants and Children With HIV
… fixed-dose combination (FDC) tablet BIC/emtricitabine (FTC)/tenofovir alafenamide (TAF). INSTI-based regimens have … that include TAF have varying weight and age requirements. Tenofovir disoproxil fumarate (TDF) plus 3TC or FTC for … (DRV/r), or lopinavir/ritonavir (LPV/r) increases plasma tenofovir (TFV) concentrations and the risk of …
What to Start: Nucleoside Reverse Transcriptase Inhibitor Options
… reverse transcriptase inhibitor; RPV = rilpivirine; TAF = tenofovir alafenamide; TC = total cholesterol; TDF = tenofovir disoproxil fumarate Summary The U.S. Food and Drug … (ZDV), stavudine (d4T), didanosine (ddI), abacavir (ABC), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide …
What to Start: Integrase Strand Transfer Inhibitor Regimens
… RAL = raltegravir; STR = single-tablet regimen; TAF = tenofovir alafenamide; UGT = uridine diphosphate … INSTIs BIC and DTG have high barriers to resistance, BIC/tenofovir alafenamide (TAF)/‌emtricitabine (FTC) and DTG plus TAF/FTC or tenofovir disoproxil fumarate (TDF)/FTC are recommended for …
What to Start: Non-Nucleoside Reverse Transcriptase Inhibitor Regimens
… rate; RPV = rilpivirine; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate Summary Four non-nucleoside … the DRIVE-AHEAD trial, 734 participants received either DOR/tenofovir disoproxil fumarate (TDF)/lamivudine (3TC) or …
What to Start: Protease Inhibitor–Based Regimens
… inhibitor; PK = pharmacokinetic; RTV = ritonavir; TAF = tenofovir alafenamide Summary The U.S. Food and Drug … each administered in combination with two NRTIs—either tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) or … Adults and Adolescents (the Panel) classifies DRV/r with (tenofovir alafenamide [TAF] or TDF) plus (FTC or 3TC) as a …
What to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal
… Antiretroviral Regimens for Initial Therapy When Abacavir, Tenofovir Alafenamide, and Tenofovir Disoproxil Fumarate Cannot Be Used or Are Not … situations where it is desirable to avoid abacavir (ABC), tenofovir alafenamide (TAF), and tenofovir disoproxil … to Start: Other Antiretroviral Regimens When Abacavir and Tenofovir Cannot Be Used or Are Not Optimal …
What to Start: Advantages and Disadvantages of Antiretroviral Components of Initial Antiretroviral Therapy
… RTV = ritonavir; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; UGT = uridine diphosphate …
Special Considerations for Antiretroviral Therapy Use in Adolescents With HIV
… Many ARV drugs (e.g., abacavir, emtricitabine, lamivudine, tenofovir disoproxil fumarate [TDF], some protease …
Virologic Failure
… barrier plus two partially active NRTIs—particularly tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF) with lamivudine (3TC) or … an HBV-active drug with a high barrier to resistance (e.g., tenofovir alafenamide [TAF], tenofovir disoproxil fumarate …
Suboptimal CD4 Cell Recovery Despite Viral Suppression
… al. Switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from dolutegravir plus abacavir and …
Optimizing Antiretroviral Therapy in the Setting of Viral Suppression
… if an NRTI is to be included in the new regimen, two NRTIs (tenofovir alafenamide [TAF] or tenofovir disoproxil fumarate [TDF] plus emtricitabine [FTC] … coinfection (hepatitis B surface antigen [HBsAg] positive), tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide …