Updated
Reviewed
Sep. 27, 2019
Tables
Table 3. Dosing Recommendations for Anti-TB Drugs for Treatment of Active Drug Sensitive TB
TB Drug | ARV Drugs | Daily Dose |
---|---|---|
Isoniazid | All ARVs | 5 mg/kg (usual dose 300 mg) |
Rifampina,b Note: DTG, RAL, and MVC doses need to be adjusted when used with rifampin |
With HIV PIs, DOR, ETR, RPV, BIC, or EVG/c | Not recommended |
With TAF | Use with cautionc at dose indicated below | |
With other ARV drugs | 10 mg/kg (usual dose 600 mg) | |
Rifabutina Note: DOR and RPV doses need to be adjusted when used with rifabutin |
With PI with COBI, TAF, BIC, or EVG/c - containing regimens | Not recommended |
With DTG, RAL, EFV, DOR, RPV | 5 mg/kg (usual dose 300 mg) | |
With HIV PIs with RTV | 150 mgd | |
With EFV | 450–600 mg | |
Pyrazinamide | All ARVs | Weight-Based Dosing
|
Ethambutol | All ARVs | Weight-Based Dosing
|
a For more detailed guidelines on use of different ARV drugs with rifamycin, clinicians should refer to the Drug-Drug Interactions section of the Adult and Adolescent Antiretroviral Guidelines b Higher doses may be needed in the treatment of TB meningitis. Expert consultation is advised. c This combination has not been tested in patients to confirm PK and virologic efficacy among patients taking full dose ART and TB regimens d Acquired rifamycin resistance has been reported in patients with inadequate rifabutin levels while on 150 mg twice weekly dosing together with RTV-boosted PIs. May consider TDM when rifabutin is used with an RTV-boosted PI and adjust dose accordingly. e Monitor for therapeutic response and consider TDM to assure dosage adequacy in patients weighing >90 kg. Key: ARV = antiretroviral; ART = antiretroviral therapy; BIC = bictegravir; COBI = cobicistat; DOR = doravirine; DTG = dolutegravir; EFV = efavirenz; ETR = etravirine; EVG = elvitegravir; EVG/c = elvitegravir/cobicistat; FTC = emtricitabine; MVC = maraviroc; PI = protease inhibitor; PK = pharmacokinetic; RAL = raltegravir; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TB = tuberculosis; TDM = therapeutic drug monitoring |
Tables
Table 3. Dosing Recommendations for Anti-TB Drugs for Treatment of Active Drug Sensitive TB
TB Drug | ARV Drugs | Daily Dose |
---|---|---|
Isoniazid | All ARVs | 5 mg/kg (usual dose 300 mg) |
Rifampina,b Note: DTG, RAL, and MVC doses need to be adjusted when used with rifampin |
With HIV PIs, DOR, ETR, RPV, BIC, or EVG/c | Not recommended |
With TAF | Use with cautionc at dose indicated below | |
With other ARV drugs | 10 mg/kg (usual dose 600 mg) | |
Rifabutina Note: DOR and RPV doses need to be adjusted when used with rifabutin |
With PI with COBI, TAF, BIC, or EVG/c - containing regimens | Not recommended |
With DTG, RAL, EFV, DOR, RPV | 5 mg/kg (usual dose 300 mg) | |
With HIV PIs with RTV | 150 mgd | |
With EFV | 450–600 mg | |
Pyrazinamide | All ARVs | Weight-Based Dosing
|
Ethambutol | All ARVs | Weight-Based Dosing
|
a For more detailed guidelines on use of different ARV drugs with rifamycin, clinicians should refer to the Drug-Drug Interactions section of the Adult and Adolescent Antiretroviral Guidelines b Higher doses may be needed in the treatment of TB meningitis. Expert consultation is advised. c This combination has not been tested in patients to confirm PK and virologic efficacy among patients taking full dose ART and TB regimens d Acquired rifamycin resistance has been reported in patients with inadequate rifabutin levels while on 150 mg twice weekly dosing together with RTV-boosted PIs. May consider TDM when rifabutin is used with an RTV-boosted PI and adjust dose accordingly. e Monitor for therapeutic response and consider TDM to assure dosage adequacy in patients weighing >90 kg. Key: ARV = antiretroviral; ART = antiretroviral therapy; BIC = bictegravir; COBI = cobicistat; DOR = doravirine; DTG = dolutegravir; EFV = efavirenz; ETR = etravirine; EVG = elvitegravir; EVG/c = elvitegravir/cobicistat; FTC = emtricitabine; MVC = maraviroc; PI = protease inhibitor; PK = pharmacokinetic; RAL = raltegravir; RPV = rilpivirine; RTV = ritonavir; TAF = tenofovir alafenamide; TB = tuberculosis; TDM = therapeutic drug monitoring |
Download Guidelines
- Section OnlyPDF (110.87 KB)
- Full GuidelinePDF (3.78 MB)
- Tables OnlyPDF (481.21 KB)