Drug information

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VFEND
Drug Class:
Antifungal (Azole)
What is voriconazole?What is voriconazole?

What is voriconazole?

Voriconazole is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain fungal infections, such as esophageal candidiasis (infection of the esophagus) and invasive candidiasis.

Esophageal candidiasis and invasive candidiasis can be opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? fact sheet.

How is voriconazole used in people with HIV?How is voriconazole used in people with HIV?

How is voriconazole used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV and the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children include recommendations on the uses of voriconazole to:

Treat:

Prevent:
  • Coccidioidomycosis from recurring
  • Histoplasmosis from recurring

The recommended uses may not always be consistent with FDA-approved uses of voriconazole. See the Adult and Pediatric Opportunistic Infection Guidelines for complete information on recommended uses of voriconazole in adults and children with HIV. Voriconazole may have other recommended uses not listed above.

What should I tell my health care provider before using voriconazole?What should I tell my health care provider before using voriconazole?

What should I tell my health care provider before using voriconazole?

Before using voriconazole, tell your health care provider:

  • If you are allergic to voriconazole or any other medicines.
  • About any medical conditions you have or have had, including:
    • Heart problems
    • Kidney or liver problems
    • Low levels of potassium, magnesium, or calcium.
  • If you have trouble digesting dairy products, milk sugar (lactose), or table sugar.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing pills, difficulty remembering to take pills, or any health conditions that may prevent your use of intravenous medicines.
  • If you are pregnant or plan to become pregnant. Voriconazole can harm your unborn baby. Talk to your health care provider about the risks with using voriconazole during pregnancy. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV may include other recommendations on the use of voriconazole during pregnancy. Please refer to these guidelines for additional information.
  • If you are breastfeeding or plan to breastfeed. For women with HIV in the United States, the Guideline does not recommend breastfeeding. Before your baby is born, or if you are already breastfeeding, talk to your health care provider to discuss alternative options for feeding your baby.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Voriconazole may affect the way other medicines or products work, and other medicines or products may affect how voriconazole works. Ask your health care provider if there are interactions between voriconazole and the other medicines you take.

Ask your health care provider about possible side effects from voriconazole. Your health care provider will tell you what to do if you have side effects.

How should I use voriconazole?How should I use voriconazole?

How should I use voriconazole?

Use voriconazole according to your health care provider’s instructions. Your health care provider will tell you how much voriconazole to use and when to use it. Before you start voriconazole and each time you get a refill, read any printed information that comes with your medicine.

How should voriconazole be stored?How should voriconazole be stored?

How should voriconazole be stored?

  • Store unopened vials of voriconazole for injection at 59°F to 86°F (15°C to 30°C). Once the injection powder in the vial has been reconstituted with Water for Injection, the solution should be used immediately. Only clear solution without particles should be used.
  • Store voriconazole tablets at 59°F to 86°F (15°C to 30°C).
  • Store voriconazole powder for oral suspension in a refrigerator at 36°F to 46°F (2°C to 8°C) before reconstitution. After reconstitution, the oral suspension should be stored at 59°F to 86°F (15°C to 30°C). Do not refrigerate or freeze it. Any remaining oral suspension should be thrown away 14 days after reconstitution.
  • Keep voriconazole in the container that it came in and keep the container tightly closed.
  • Do not use voriconazole if the original seal over the container opening is broken or missing.
  • Throw away voriconazole that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep voriconazole and all medicines out of reach of children.
Where can I find more information about voriconazole?Where can I find more information about voriconazole?

Where can I find more information about voriconazole?

Last Reviewed: November 12, 2021