ClinicalInfo offers access to the latest, federally approved HIV/AIDS medical practice guidelines, an HIV drug database, a glossary of HIV-related terms, and resources related to HIV-related research for health care providers, researchers, people affected by HIV/AIDS, and the general public.

ClinicalInfo, a service of the U.S. Department of Health and Human Services (HHS), is maintained by the Office of AIDS Research (OAR), which is part of the National Institutes of Health (NIH). OAR coordinates HIV/AIDS research across the National Institutes of Health (NIH). The NIH provides the largest public investment in HIV/AIDS research globally. ClinicalInfo is presented on HIV.gov, an important source of HIVinformation that helps users access and navigate the wide variety of Federal HIV programs, services, and policies.

ClinicalInfo is 100% federally funded and sponsored by the Office of AIDS Research (OAR).


The AIDS Clinical Trials Information Service (ACTIS) was mandated by the Health Omnibus Programs Extension Act (HOPE) in 1988. This legislation required the U.S. Food and Drug Administration (FDA) to provide a telephone reference service to disseminate HIV/AIDS clinical trials information to health professionals and the general public. ACTIS, which was created by an interagency team at NIAID, FDA, NLM, and CDC, opened in 1989. During the 11 years of its existence, the service responded to more than 225,000 telephone requests for HIV/AIDS clinical trials information. 

As new therapies and guidelines for the treatment of HIV/AIDS were approved, the need to provide up-to-date information in these areas became apparent. In 1994, six Public Health Service (PHS) agencies joined together to launch the HIV/AIDS Treatment Information Service (ATIS) as a vehicle to quickly convey this information to people living with HIV and health care providers. ATIS became the central dissemination point for the PHS treatment guidelines through the telephone reference service and the ATIS website. ATIS was supported by funding from many PHS agencies including NIH, the Health Care Financing Administration (HCFA, now the Centers for Medicare and Medicaid Services – CMS), CDC, and HRSA. 

ACTIS and ATIS were merged into a single information service, AIDSinfo.nih.gov which became operational on December 1, 2002. The Spanish-language companion website infoSIDA.nih.gov, was launched in April 2007.

In September 2020 the Office of AIDS Research (OAR) transitioned the public AIDSinfo.nih.gov and infoSIDA.nih.gov websites from the National Library of Medicine (NLM) to OAR and the Department of Health and Human Services (HHS) Office of Infectious Diseases and HIV/AIDS Policy (OIDP), which manages HIV.gov. The websites have been renamed ClinicalInfo.HIV.gov and HIVinfo.nih.gov. ClinicalInfo features the HIV Clinical Treatment Guidelines, the HIV Drug Database, and the Glossary. HIVinfo features the Understanding HIV components including easy-to-understand fact sheets and infographics. Both sites feature Spanish pages that can be accessed using the Spanish (es) dropdown.


ClinicalInfo services and staff cannot replace direct communication with your health care provider(s). The staff cannot respond to specific medical questions, offer medical advice, give second opinions, or make recommendations about specific therapies.

ClinicalInfo neither allows advertising on the website, nor endorses any company or products.