ClinicalInfo offers access to the latest, federally approved HIV/AIDS medical practice guidelines, HIV treatment and prevention clinical trials, and other research information for health care providers, researchers, people affected by HIV/AIDS, and the general public.

ClinicalInfo, a service of the U.S. Department of Health and Human Services (HHS), is maintained by the National Library of Medicine (NLM), which is part of the National Institutes of Health (NIH). The world’s largest biomedical library, NLM maintains and makes available a vast print collection and produces electronic information resources on a wide range of topics that are searched billions of times each year by millions of people around the globe. NLM also supports and conducts research, development, and training in biomedical informatics and health information technology. The Library coordinates a National Network of Libraries of Medicine, a nationwide network of health sciences libraries and information centers with a mission to advance the progress of medicine and improve the public’s health by providing all U.S. health professionals with equal access to biomedical information and improving the public's access to information to enable them to make informed decisions about their health. 

ClinicalInfo is 100% federally funded and sponsored by the Office of AIDS Research (OAR) and the National Institute of Allergy and Infectious Diseases (NIAID)—both part of NIH, the Health Resources and Services Administration (HRSA), and the Centers for Disease Control and Prevention (CDC)

To learn more about this service, please read the HIVinfo brochure which provides more information about ClinicalInfo services and features and is available to download in a print-friendly format.


ClinicalInfo services and staff cannot replace direct communication with your health care provider(s). The staff cannot respond to specific medical questions, offer medical advice, give second opinions, or make recommendations about specific therapies.

ClinicalInfo neither allows advertising on the website, nor endorses any company or products.


The AIDS Clinical Trials Information Service (ACTIS) was mandated by the Health Omnibus Programs Extension Act (HOPE) in 1988. This legislation required the U.S. Food and Drug Administration (FDA) to provide a telephone reference service to disseminate HIV/AIDS clinical trials information to health professionals and the general public. ACTIS, which was created by an interagency team at NIAID, FDA, NLM, and CDC, opened in 1989. During the 11 years of its existence, the service responded to more than 225,000 telephone requests for HIV/AIDS clinical trials information. 

As new therapies and guidelines for the treatment of HIV/AIDS were approved, the need to provide up-to-date information in these areas became apparent. In 1994, six Public Health Service (PHS) agencies joined together to launch the HIV/AIDS Treatment Information Service (ATIS) as a vehicle to quickly convey this information to people living with HIV and health care providers. ATIS became the central dissemination point for the PHS treatment guidelines through the telephone reference service and the ATIS website. ATIS was supported by funding from many PHS agencies including NIH, the Health Care Financing Administration (HCFA, now the Centers for Medicare and Medicaid Services – CMS), CDC, and HRSA. 

ACTIS and ATIS were merged into a single information service, ClinicalInfo, which became operational on December 1, 2002. The Spanish-language companion website to ClinicalInfo, was launched in April 2007.